Cell invasion through basement membrane barriers is crucial during many developmental
processes and in immune surveillance. Dysregulation of invasion also drives the pathology …

Introduction Histone deacetylase (HDAC) inhibitors have been considered as an attractive
strategy to reverse aberrant epigenetic changes associated with cancer treatments. The use …

Isoform-selective histone deacetylase (HDAC) inhibition is promoted as a rational strategy to
develop safer anti-cancer drugs compared to non-selective HDAC inhibitors. Despite this …

Purpose Cisplatin is the core chemotherapeutic drug used for first-line treatment of
advanced non-small cell lung cancer (NSCLC). However, drug resistance is severely …

Simple Summary Although in the last decades the clinical outcome of cancer patients
considerably improved, the major drawbacks still associated with chemotherapy are the …

Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) for
treating advanced non-small cell lung cancer (NSCLC). However, drug resistance seriously …

The Purinergic pathway is involved in a variety of important physiological processes in living
organisms, and previous studies have shown that aberrant expression of the Purinergic …

Cervical cancer (CC) is the fourth most common cancer amongst females worldwide.
Histone deacetylase (HDAC) 1 plays a vital role in several tumors. Nevertheless, its potential …

Ovarian cancer is the most lethal gynecologic malignancy, and metastasis is the major
cause of death in patients with ovarian cancer, which is regulated by the coordinated …

A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and, as such,
provides a semi-selective barrier between the blood and the interstitial space. Compromise …