[HTML][HTML] Sinomenine ameliorates rheumatoid arthritis by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation

ZM Jiang, SL Zeng, TQ Huang, Y Lin, FF Wang, XJ Gao… - Science Bulletin, 2023 - Elsevier
Gut microbiota dysbiosis is associated with the development of rheumatoid arthritis (RA).
Sinomenine (SIN) is an effective immunosuppressive and anti-inflammatory drug used for …

[HTML][HTML] Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses

Y Chen, Y Ye, H Liu, Z Luo, Q Li, Q Xie - Journal of Immunology …, 2024 - hindawi.com
This study systematically analyzes the association between interleukin-18 (IL-18) gene
polymorphisms and rheumatoid arthritis (RA) susceptibility. The electronic databases Ovid …

Genetic susceptibility to autoimmunity—Current status and challenges

M Huang, H Xu - Advances in Immunology, 2022 - Elsevier
Autoimmune diseases (ADs) often arise from a combination of genetic and environmental
triggers that disrupt the immune system's capability to properly tolerate body self-antigens …

Association between non-coding transcript variant polymorphisms (rs3135499, rs3135500) of the NOD2 gene and the propensity to rheumatoid arthritis in the Iraqi …

HW Khalaf, DAF Al-Koofee, Ö Seçmeler - Human Gene, 2024 - Elsevier
Aim The objective of this study was to explore how the existence of two particular SNPs
located in potential binding sites for microRNAs in the 3′-UTR region of the NOD2 gene …

[PDF][PDF] Prediction of new risk genes and potential drugs for rheumatoid arthritis from multiomics data

AM Birga, L Ren, H Luo, Y Zhang… - … Methods in Medicine, 2022 - downloads.hindawi.com
Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease for which there is a
lack of therapeutic options. Genomewide association studies (GWASs) have identified over …

Assessment of the association between TNIP1 polymorphism with clinical features and risk of systemic lupus erythematosus

S Azhdari, M Saghi, B Alani, M Zare Rafie… - Lupus, 2022 - journals.sagepub.com
Objective Over the past decades, TNIP1 has been identified as a strong risk locus in multiple
genome-wide association studies (GWAS), spanning multiple populations and various …

Microorganisms in Pathogenesis and Management of Rheumatoid Arthritis

B Balakrishnan, V Taneja - Role of Microorganisms in Pathogenesis and …, 2022 - Springer
Interactions between genetic and environmental factors are implicated in the onset of
rheumatoid arthritis (RA). There is an increasing appreciation for the association between …

Aetiopathology of rheumatoid arthritis

PC Taylor, S Kiriakidis - Medicine, 2022 - Elsevier
Rheumatoid arthritis (RA) has a multifactorial aetiopathogenesis with both genetic and
environmental factors implicated, giving rise to immune dysregulation with resultant joint …

[PDF][PDF] Study of transforming growth factor beta 1 gene+ 869T/C polymorphism in Egyptian rheumatoid arthritis patients and its relation to disease activity

AS Hassan, AM Abdul-Mohymen… - Egyptian Journal of …, 2022 - ejimmunology.org
This study intended to explore the relationship between the+ 869T/C polymorphism of the
transforming growth factor-β1 (TGF-β1) gene and rheumatoid arthritis (RA) predisposition …