[HTML][HTML] Lateral flow test engineering and lessons learned from COVID-19

J Budd, BS Miller, NE Weckman, D Cherkaoui… - Nature Reviews …, 2023 - nature.com
The acceptability and feasibility of large-scale testing with lateral flow tests (LFTs) for clinical
and public health purposes has been demonstrated during the COVID-19 pandemic. LFTs …

Strategies for developing sensitive and specific nanoparticle-based lateral flow assays as point-of-care diagnostic device

JH Soh, HM Chan, JY Ying - Nano Today, 2020 - Elsevier
From a home-based pregnancy self-testing kit, lateral flow assays (LFAs) have proliferated
and gained widespread utilization as point-of-care (POC) test kits. Their prevalence is due to …

Platinum nanocatalyst amplification: redefining the gold standard for lateral flow immunoassays with ultrabroad dynamic range

CN Loynachan, MR Thomas, ER Gray, DA Richards… - ACS …, 2018 - ACS Publications
Paper-based lateral flow immunoassays (LFIAs) are one of the most widely used point-of-
care (PoC) devices; however, their application in early disease diagnostics is often limited …

[HTML][HTML] Principles of mitoribosomal small subunit assembly in eukaryotes

NJ Harper, C Burnside, S Klinge - Nature, 2023 - nature.com
Mitochondrial ribosomes (mitoribosomes) synthesize proteins encoded within the
mitochondrial genome that are assembled into oxidative phosphorylation complexes. Thus …

Principles of human pre-60S biogenesis

A Vanden Broeck, S Klinge - Science, 2023 - science.org
During the early stages of human large ribosomal subunit (60 S) biogenesis, an ensemble of
assembly factors establishes and fine-tunes the essential RNA functional centers of pre-60 S …

[HTML][HTML] Single-domain near-infrared protein provides a scaffold for antigen-dependent fluorescent nanobodies

OS Oliinyk, M Baloban, CL Clark, E Carey, S Pletnev… - Nature …, 2022 - nature.com
Small near-infrared (NIR) fluorescent proteins (FPs) are much needed as protein tags for
imaging applications. We developed a 17 kDa NIR FP, called miRFP670nano3, which …

[HTML][HTML] Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 …

L Cheng, X Zhang, Y Chen, D Wang, D Zhang… - … and Targeted Therapy, 2021 - nature.com
A comprehensive analysis of the humoral immune response to the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is essential in understanding COVID-19 …

[HTML][HTML] Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design

F Vascon, M Gasparotto, M Giacomello… - Computational and …, 2020 - Elsevier
Computationally driven engineering of proteins aims to allow them to withstand an extended
range of conditions and to mediate modified or novel functions. Therefore, it is crucial to the …

[HTML][HTML] Prospects of neutralizing nanobodies against SARS-CoV-2

F Chen, Z Liu, F Jiang - Frontiers in immunology, 2021 - frontiersin.org
Since December 2019, the SARS-CoV-2 has erupted on a large scale worldwide and
spread rapidly. Passive immunization of antibody-related molecules provides opportunities …

[HTML][HTML] FEZ1 is recruited to a conserved cofactor site on capsid to promote HIV-1 trafficking

PT Huang, BJ Summers, C Xu, JR Perilla, V Malikov… - Cell reports, 2019 - cell.com
HIV-1 uses the microtubule network to traffic the viral capsid core toward the nucleus. Viral
nuclear trafficking and infectivity require the kinesin-1 adaptor protein FEZ1. Here, we …