p24 revisited: a landscape review of antigen detection for early HIV diagnosis

ER Gray, R Bain, O Varsaneux, RW Peeling… - Aids, 2018 - journals.lww.com
Despite major advances in HIV testing, early detection of infection at the point of care (PoC)
remains a key challenge. Although rapid antibody PoC and laboratory-based nucleic acid …

Nanobodies that neutralize HIV

RA Weiss, CT Verrips - Vaccines, 2019 - mdpi.com
Nanobodies or VHH (variable domains of heavy-chain only antibodies) are derived from
camelid species such as llamas and camels. Nanobodies isolated and selected through …

Nanobodies: prospects of expanding the gamut of neutralizing antibodies against the novel coronavirus, SARS-CoV-2

R Konwarh - Frontiers in immunology, 2020 - frontiersin.org
With more than 6.9 M confirmed cases and∼ 400K deaths as on June 8, 2020 (1), COVID-
19, ushered in by the SARS-CoV-2 has projected itself as a microscopic-holocaust, much …

Controlling the Binding Efficiency of Surface Confined Antibodies through the Design of Mixed Self‐Assembled Monolayers

L Sarcina, P Delre, G Graziano… - Advanced Materials …, 2023 - Wiley Online Library
A plethora of different electronic and optoelectronic devices have been developed lately, for
biosensing applications (eg, label‐free, fast, and easier to operate) based on a detecting …

Towards an ultra-rapid smartphone-connected test for infectious diseases

V Turbé, ER Gray, VE Lawson, E Nastouli… - Scientific reports, 2017 - nature.com
The development is reported of an ultra-rapid, point-of-care diagnostic device which
harnesses surface acoustic wave (SAW) biochips, to detect HIV in a finger prick of blood …

Targeting Ras-binding domain of ELMO1 by computational nanobody design

C Tam, M Kukimoto-Niino, Y Miyata-Yabuki… - Communications …, 2023 - nature.com
The control of cell movement through manipulation of cytoskeletal structure has therapeutic
prospects notably in the development of novel anti-metastatic drugs. In this study, we …

Nanobodies: cOVID-19 and future perspectives

G Valenzuela-Nieto, Z Miranda-Chacon… - Frontiers in Drug …, 2022 - frontiersin.org
The COVID-19 pandemic has driven biotechnological developments to provide new and
more effective tools for prophylaxis, diagnosis, and therapy. Historically, monoclonal …

Tuning nanobodies' bioactivity: Coupling to ultrasmall gold nanoparticles allows the intracellular interference with survivin

P Stahl, S Kollenda, J Sager, L Schmidt, MA Schroer… - Small, 2023 - Wiley Online Library
Nanobodies are highly affine binders, often used to track disease‐relevant proteins inside
cells. However, they often fail to interfere with pathobiological functions, required for their …

Modular HIV-1 capsid assemblies reveal diverse host-capsid recognition mechanisms

BJ Summers, KM Digianantonio, SS Smaga… - Cell host & …, 2019 - cell.com
The HIV-1 capsid is an ordered protein shell that houses the viral genome during early
infection. Its expansive surface consists of an ordered and interfacing array of capsid protein …

Transforming nanobodies into high-precision tools for protein function analysis

J Gettemans, B De Dobbelaer - American Journal of …, 2021 - journals.physiology.org
Single-domain antibodies, derived from camelid heavy antibodies (nanobodies) or shark
variable new antigen receptors, have attracted increasing attention in recent years due to …