One of the challenges faced by current CRISPR/Cas9 editing strategies is the difficulty in
rapidly selecting clonal populations of biallelically edited cells. Here we present Surface …

With the rise of viral infections and antibiotic resistance, there is a constant need for the
development of more sensitive and effective treatment and diagnostic tools. Since their …

The rapid emergence of drug-resistant variants is one of the most common causes of highly
active antiretroviral therapeutic (HAART) failure in patients infected with HIV-1. Compared …

The capsid (CA) domain of the HIV-1 precursor Gag (PrGag) protein plays multiple roles in
HIV-1 replication, and is central to the assembly of immature virions, and mature virus cores …

Nanobodies are the smallest known antigen-binding molecules to date. Their small size,
good tissue penetration, high stability and solubility, ease of expression, refolding ability …

Conformational flexibility plays an essential role in antibodies' functional and structural
stability. They facilitate and determine the strength of antigen–antibody interactions …

Nanobodies, the smallest functional antibody fragment derived from camelid heavy‐chain‐
only antibodies, have emerged as powerful tools for diverse biomedical applications. In this …

Protein-protein interactions are fundamental to life processes. Complementary
computational, structural, and biophysical studies of these interactions enable the forces …

Background Recently, new and advanced techniques have been adopted to design and
produce nanobodies, which are used in diagnostic and immunotherapy treatments …

Molecular dynamics simulation is an important tool for studying nanomedicines at the atomic
scale. Because measuring parameters at the atomic scale is very costly, the use of …