The debate over the cardiovascular (CV) implications of testosterone therapy (TT) have
resulted in diverging safety recommendations and clinical guidelines worldwide. This …

Steroid hormone levels are closely related to the endogenous circadian rhythm induced by
sleep–wake and dark–light cycles. Shift work that disrupts the circadian rhythm may …

One-carbon (1-C) metabolic deficiency impairs homeostasis, driving disease development,
including infertility. It is of importance to summarize the current evidence regarding the …

Although testosterone replacement in men with classic hypogonadism due to an identified
pathology of the hypothalamic-pituitary-testicular axis is uncontroversial, the role of …

Context Trinucleotide repeats in the androgen receptor have been proposed to influence
testosterone signaling in men, but the clinical relevance of these trinucleotide repeats …

The male reproductive system experiences degradation with age, predominantly impacting
the testes. Testicular aging can result in failure to produce physiological testosterone levels …

Introduction Androgens play important roles in regulating the growth and development of the
male reproductive system and maintaining libido and erectile function. The specific …

Introduction Fertility rates in developing countries have declined over the past decades, and
the trend of delayed fatherhood is rising as societies develop. The reasons behind the …

Obesity-related gonadal dysfunction in males has been defined recently as male obesity
secondary hypogonadism (MOSH). Affected individuals present with signs and symptoms …

Background: T-score discordance is common in osteoporosis diagnosis and leads to
problems for clinicians formulating treatment plans. Objectives: This study investigated the …