Applications of molecular dynamics simulation in protein study
Molecular Dynamics (MD) Simulations is increasingly used as a powerful tool to study
protein structure-related questions. Starting from the early simulation study on the …
protein structure-related questions. Starting from the early simulation study on the …
[HTML][HTML] Emerging SARS-CoV-2 variants: Why, how, and what's next?
The emergence of the SARS-CoV-2 Omicron variant poses a striking threat to human
society. More than 30 mutations in the Spike protein of the Omicron variant severely …
society. More than 30 mutations in the Spike protein of the Omicron variant severely …
[HTML][HTML] Variations within the glycan shield of SARS-CoV-2 impact viral spike dynamics
The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity, whether
arisen naturally or through vaccination. Understanding the structure of the viral spike assists …
arisen naturally or through vaccination. Understanding the structure of the viral spike assists …
Improved binding affinity of omicron's spike protein for the human angiotensin-converting enzyme 2 receptor is the key behind its increased virulence
The new variant of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2),
Omicron, has been quickly spreading in many countries worldwide. Compared to the …
Omicron, has been quickly spreading in many countries worldwide. Compared to the …
Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesis
Z Zhang, J Zhang, J Wang - Frontiers in Public Health, 2022 - frontiersin.org
With the COVID-19 pandemic continuing, more contagious SARS-CoV-2 variants, including
Omicron, have been emerging. The mutations, especially those that occurred on the spike …
Omicron, have been emerging. The mutations, especially those that occurred on the spike …
When the dust has settled: calculation of binding affinities from first principles for SARS-CoV-2 variants with quantitative accuracy
EG Coderc de Lacam, M Blazhynska… - Journal of Chemical …, 2022 - ACS Publications
Accurate determination of binding free energy is pivotal for the study of many biological
processes and has been applied in a number of theoretical investigations to compare the …
processes and has been applied in a number of theoretical investigations to compare the …
Antibody evasion associated with the RBD significant mutations in several emerging SARS-CoV-2 variants and its subvariants
Since the origin of the wild strain of SARS-CoV-2, several variants have emerged, which
were designated as VOC, VOI, and VUM from time to time. The Omicron variant is noted as …
were designated as VOC, VOI, and VUM from time to time. The Omicron variant is noted as …
Continent-wide evolutionary trends of emerging SARS-CoV-2 variants: Dynamic profiles from Alpha to Omicron
The ongoing SARS-CoV-2 evolution process has generated several variants due to its
continuous mutations, making pandemics more critical. The present study illustrates SARS …
continuous mutations, making pandemics more critical. The present study illustrates SARS …
Molecular epidemiology of SARS-CoV-2 in Tunisia (North Africa) through several successive waves of COVID-19
A Chouikha, W Fares, A Laamari, S Haddad-Boubaker… - Viruses, 2022 - mdpi.com
Documenting the circulation dynamics of SARS-CoV-2 variants in different regions of the
world is crucial for monitoring virus transmission worldwide and contributing to global efforts …
world is crucial for monitoring virus transmission worldwide and contributing to global efforts …
Comparative assessment of severe acute respiratory syndrome coronavirus 2 variants in the ferret model
JA Pulit-Penaloza, JA Belser, X Sun, C Pappas… - MBio, 2022 - Am Soc Microbiol
The continued spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in
humans necessitates evaluation of variants for enhanced virulence and transmission. We …
humans necessitates evaluation of variants for enhanced virulence and transmission. We …