Rheumatoid arthritis (RA) is the most common inflammatory arthropathy worldwide. Possible
manifestations of RA can be represented by a wide variability of symptoms, clinical forms …

Methotrexate (MTX), a structural analog of folic acid, is widely employed in the treatment of
different cancers and autoimmune diseases. Despite the successful results observed, the …

Background: Methotrexate (MTX) is widely used and considered a first-line disease
modifying antirheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA) …

Background For decades, methotrexate (MTX; amethopterin) has been known as an
antifolate inhibitor of dihydrofolate reductase (DHFR), and it is widely used for the treatment …

Rheumatoid arthritis (RA) is a chronic inflammatory disease that is very complex and
heterogeneous. If not adequately treated, RA patients are likely to manifest excess of …

Methotrexate (MTX), the most commonly used anti-rheumatic drug against RA, enters the
cell via the action of the reduced folate carrier 1 (RFC1). A major polymorphism of the RFC1 …

For many decades, methotrexate (MXT) has remained the drug of choice in the treatment of
rheumatoid arthritis (RA). Unfortunately, a considerable number of patients do not achieve …

Introduction Methotrexate (MTX) is a folate antagonist and a first-line drug for the treatment
of rheumatoid arthritis (RA). However, in up to 30% of cases, MTX monotherapy is …

Polygenic models have emerged as promising prediction tools for the prediction of complex
traits. Currently, the majority of polygenic models are developed in the context of predicting …

The ATP-binding cassette (ABC) and solute carrier (SLC) transporter families consist of
common drug transporters that mediate the efflux and uptake of drugs, respectively, and play …