Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications

N Potere, MG Del Buono, R Caricchio, PC Cremer… - …, 2022 - thelancet.com
A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal Transduction and Targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

Activation of innate immune cGAS-STING pathway contributes to Alzheimer's pathogenesis in 5× FAD mice

X Xie, G Ma, X Li, J Zhao, Z Zhao, J Zeng - Nature Aging, 2023 - nature.com
Abstract cGAS senses microbial and host-derived double-stranded DNA in cytoplasm to
trigger cellular innate immune response in a STING-dependent manner; however, it remains …

Hyperinflammatory response in COVID-19: a systematic review

MJA Silva, LR Ribeiro, MIM Gouveia, BR Marcelino… - Viruses, 2023 - mdpi.com
COVID-19 is a multisystemic disease caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The immunopathogenic conditions of the hyperinflammatory …

The potential role of growth differentiation factor 15 in COVID-19: a corollary subjective effect or not?

AO Babalghith, HM Al-Kuraishy, AI Al-Gareeb… - Diagnostics, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) is primarily caused by various forms of severe acute
respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants. COVID-19 is characterized …

Cyanidin-3-O-glucoside and peonidin-3-O-glucoside-rich fraction of black rice germ and bran suppresses inflammatory responses from SARS-CoV-2 spike …

W Semmarath, S Mapoung, S Umsumarng, P Arjsri… - Nutrients, 2022 - mdpi.com
Black rice is a functional food that is high in anthocyanin content, primarily C3G and P3G. It
possesses nutraceutical properties that exhibit a range of beneficial effects on human …

[HTML][HTML] NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes

D Dutta, J Liu, H Xiong - International journal of physiology …, 2022 - ncbi.nlm.nih.gov
Despite the introduction of vaccines and drugs for SARS-CoV-2, the COVID-19 pandemic
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …

Ferroptosis and pyroptosis signatures in critical COVID-19 patients

C Peleman, S Van Coillie, S Ligthart, SM Choi… - Cell Death & …, 2023 - nature.com
Critical COVID-19 patients admitted to the intensive care unit (ICU) frequently suffer from
severe multiple organ dysfunction with underlying widespread cell death. Ferroptosis and …