Adeno-associated viruses (AAVs) represent some of the most commonly employed vectors
for targeted gene delivery and their extensive study has resulted in the approval of multiple …

NLRP3 inflammasome-mediated immune responses are involved in the pathogenesis of
multiple inflammatory diseases, but few clinical drugs are identified that directly target the …

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), remains a significant global health emergency with new …

Simple Summary Inflammasomes are multiprotein complexes that sense endogenous
damage stimuli and diverse microbial pathogens, including viruses. A growing body of …

Background Accumulating evidence indicates that intervertebral disc degeneration (IDD) is
associated with diabetes mellitus (DM), while the underlying mechanisms still remain …

The continuously arising of SARS-CoV-2 variants has been posting a great threat to public
health safety globally, from B. 1.17 (Alpha), B. 1.351 (Beta), P. 1 (Gamma), B. 1.617. 2 …

Following the outbreak of the COVID-19 pandemic, millions of people around the world have
been affected with SARS-CoV-2 infection. In addition to the typical symptoms, thrombotic …

The COVID-19 pandemic caused by the SARS-CoV-2 (β-CoV) betacoronavirus has posed a
significant threat to global health. Despite the availability of vaccines, the virus continues to …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the coronavirus disease 2019 (COVID-19) pandemic that has caused disastrous effects on …

Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of
numerous diseases. However, the precise molecular mechanisms that modulate the …