Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the
prevention and treatment of various diseases, the underlying biological mechanisms have …

Abstract Platelet factor 4 (PF4) combines with heparin to form an antigen that could produce
IgG antibodies and participate in heparin-induced thrombocytopenia (HIT). PF4 has …

Background Diabetic peripheral neuropathy (DPN) is one of the most common
complications of diabetes and the main cause of non-traumatic amputation, with no ideal …

Acute myeloid leukemia (AML) is an aging-related and heterogeneous hematopoietic
malignancy. In this study, a total of 1,474 newly diagnosed AML patients with RNA …

Understanding the regulatory mechanisms facilitating hematopoietic stem cell (HSC)
specification during embryogenesis is important for the generation of HSCs in vitro …

The human population is ageing worldwide. The World Health Organization estimated that
the world's population of people aged 60 years and older will increase to at least 30 …

The increasing burden in dementia-related disorders has necessitated improved
understanding of cognitive decline. In a recent issue of Nature, Schroer et al. demonstrate …

The identification of protein targets that exhibit anti‐aging clinical potential could inform
interventions to lengthen the human health span. Most previous proteomics research has …

Platelet activation of protease-activated receptor 4 (PAR4) and thrombin are at the top of a
chain of events leading to fibrin deposition, microinfarcts, blood-brain barrier disruption, and …

Age-related loss of brain function has been seen as inevitable, yet recent work leveraging
the systemic environment challenges this notion. Schroer et al. demonstrate that youth …