Advances in acute myeloid leukemia differentiation therapy: A critical review

AK Abdel-Aziz - Biochemical Pharmacology, 2023 - Elsevier
Acute myeloid leukemia (AML) is characterized by impaired differentiation and indefinite
proliferation of abnormal myeloid progenitors. Although differentiating agents were deemed …

Quinoxaline 1, 4-dioxides: advances in chemistry and chemotherapeutic drug development

GI Buravchenko, AE Shchekotikhin - Pharmaceuticals, 2023 - mdpi.com
N-Oxides of heterocyclic compounds are the focus of medical chemistry due to their diverse
biological properties. The high reactivity and tendency to undergo various rearrangements …

Novel sulfonamide-indolinone hybrids targeting mitochondrial respiration of breast cancer cells

SWA Helmy, AK Abdel-Aziz, EME Dokla… - European Journal of …, 2024 - Elsevier
Breast cancer (BC) still poses a threat worldwide which demands continuous efforts to
present safer and efficacious treatment options via targeted therapy. Beside kinases' …

Anti-Proliferative, Anti-EGFR and In Silico Studies of a Series of New Imidazole Tethered 1, 2, 4-Oxadiazoles

S Lavunuri, RV Nadh, SK Rapeti - Polycyclic Aromatic Compounds, 2023 - Taylor & Francis
Herein, we prepared some new imidazole-1, 2, 4-oxadiazole hybrids (6a–6o) and
investigated their antiproliferative potential on three human cancer cell lines (HepG2, A549 …

Azadiradione (AZD) neem biomass derived limonoid: extraction, characterization, and potential biological activities with special reference to anti-microbial and anti …

PS Priya, RS Kumar, MRA Gawwad, KM Alarjani… - South African Journal of …, 2023 - Elsevier
The resistance of conventional drugs to bacterial infections and cancer poses a significant
threat to the healthcare system causing increased mortality. Metabolites derived from plant …

SOAT1 in gallbladder cancer: Clinicopathological significance and avasimibe therapeutics

Y Hong, X Abudukeremu, F She… - Journal of Biochemical …, 2024 - Wiley Online Library
The aim of this investigation was to evaluate the differential expression of the sterol O‐
acyltransferase 1 (SOAT1) protein in gallbladder cancer tissues and cells, investigate the …