D-and E-type cyclins mediate G1-S phase cell cycle progression through activation of
specific cyclin-dependent kinases (cdk) that phosphorylate the retinoblastoma protein (pRb) …

One of the most important tasks of modern bioinformatics is the development of
computational tools that can be used to understand and treat human disease. To date, a …

MicroRNAs have been extensively studied as regulators of hematopoiesis and
leukemogenesis. We identified miR-638 as a novel regulator in myeloid differentiation and …

Allosteric targeting of protein kinases via displacement of the structural αC helix with type III
allosteric inhibitors is currently gaining a foothold in drug discovery. Recently, the first crystal …

Effects of CB2 and TRPV1 receptors’ stimulation in pediatric acute T-lymphoblastic leukemia -
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

The beta‐amyloid peptide (Aβ) is considered responsible for the pathogenesis of
Alzheimer's disease. Despite the magnitude of reports describing a neurotoxic role of …

Germline variants of PIP4K2A impact susceptibility of acute lymphoblastic leukemia (ALL)
through inducing its overexpression. Although limited reports suggested the oncogenic role …

Adenoviruses (Ads) with deletion of E1b55K preferentially replicate in cancer cells and have
been used in cancer therapies. We have previously shown that Ad E1B55K protein is …

Alterations in cell cycle regulating proteins are a key characteristic in neoplastic proliferation
of lymphoblast cells in patients with Acute Lymphoblastic Leukemia (ALL). The aim of our …

Cyclin-dependent kinases (CDKs) successively phosphorylate the retinoblastoma protein
(RB) at the restriction point in G1 phase. Hyperphosphorylation results in functional …