Pathological mechanisms and therapeutic strategies for Alzheimer's disease

Y Ju, KY Tam - Neural regeneration research, 2022 - journals.lww.com
Alzheimer's disease is a rather complex neurodegenerative disease, which is attributed to a
combination of multiple factors. Among the many pathological pathways, synaptic …

Gut microbiota and dysbiosis in Alzheimer's disease: implications for pathogenesis and treatment

S Liu, J Gao, M Zhu, K Liu, HL Zhang - Molecular neurobiology, 2020 - Springer
Understanding how gut flora influences gut-brain communications has been the subject of
significant research over the past decade. The broadening of the term “microbiota-gut-brain …

[HTML][HTML] Type 2 diabetes and quality of life

A Trikkalinou, AK Papazafiropoulou… - World journal of …, 2017 - ncbi.nlm.nih.gov
It is true that a primary goal of diabetes early diagnosis and treatment is quality of life (QoL).
The term QoL is still confusing but it is agreed that it composes of four components: The …

Modifiable risk factors for Alzheimer's disease

GA Edwards III, N Gamez, G Escobedo Jr… - Frontiers in aging …, 2019 - frontiersin.org
Since first described in the early 1900s, Alzheimer's disease (AD) has risen exponentially in
prevalence and concern. Research still drives to understand the etiology and pathogenesis …

Type 2 diabetes mellitus and Alzheimer's disease: shared molecular mechanisms and potential common therapeutic targets

R Hamzé, E Delangre, S Tolu, M Moreau… - International journal of …, 2022 - mdpi.com
The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly
with the aging of the population. Numerous epidemiological data suggest that there is a …

Tau suppresses microtubule-regulated pancreatic insulin secretion

SP Mangiafico, QZ Tuo, XL Li, Y Liu… - Molecular …, 2023 - nature.com
Tau protein is implicated in the pathogenesis of Alzheimer's disease (AD) and other
tauopathies, but its physiological function is in debate. Mostly explored in the brain, tau is …

Alzheimer's disease and type 2 diabetes: a critical assessment of the shared pathological traits

S Chatterjee, A Mudher - Frontiers in neuroscience, 2018 - frontiersin.org
Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most
prevalent diseases in the elderly population worldwide. A growing body of epidemiological …

Metabolism: a novel shared link between diabetes mellitus and Alzheimer's disease

Y Sun, C Ma, H Sun, H Wang, W Peng… - Journal of diabetes …, 2020 - Wiley Online Library
As a chronic metabolic disease, diabetes mellitus (DM) is broadly characterized by elevated
levels of blood glucose. Novel epidemiological studies demonstrate that some diabetic …

Crosstalk between obesity, diabetes, and alzheimer's disease: Introducing quercetin as an effective triple herbal medicine

S Ebrahimpour, M Zakeri, A Esmaeili - Ageing research reviews, 2020 - Elsevier
Obesity and diabetes are the most common metabolic disorders, which are strongly related
to Alzheimer's disease (AD) in aging. Diabetes and obesity can lead to the accumulation of …

Impairment of the glymphatic system after diabetes

Q Jiang, L Zhang, G Ding… - Journal of Cerebral …, 2017 - journals.sagepub.com
The glymphatic system has recently been shown to clear brain extracellular solutes and
abnormalities in glymphatic clearance system may contribute to both initiation and …