Brain channelopathies are a group of neurological disorders that result from genetic
mutations affecting ion channels in the brain. Ion channels are specialized proteins that play …

While humans exhibit a significant degree of neuropathological changes associated with
deficits in cognitive and memory functions during aging, non‐human primates (NHP) present …

The amyloid precursor protein (APP) is linked to the genetics and pathogenesis of
Alzheimer's disease (AD). It is the parent protein of the β-amyloid (Aβ) peptide, the main …

It is well established that human life expectancy increases considerably with an ever-
growing number of people suffering from age-related cognitive decline and degenerative …

Voltage gated sodium channels (Nav) play a crucial role in action potential initiation and
propagation. Although the discovery of Nav channels dates back more than 65 years, and …

Abstract Knowledge on cortical development is based mainly on small rodents besides
primates and carnivores, all being altricial nestlings. Ungulates are precocial and born with …

The axon initial segment (AIS) is a critical locus of control of action potential (AP) generation
and neuronal information synthesis. Concussive traumatic brain injury gives rise to diffuse …

Recent studies have indicated that the structure of the axon initial segment (AIS) of neurons
is highly plastic in response to changes in neuronal activity. Whether an age-related …

Abstract Changes in mitochondrial distribution are a feature of numerous age-related
neurodegenerative diseases. In Drosophila, reducing the activity of Cdk5 causes a …

Recent evidence suggests that alteration of axon initial segment (AIS) geometry (ie, length
or location along the axon) contributes to CNS dysfunction in neurological diseases. For …