Arming human cells with synthetic gene circuits enables to expand their capacity to execute
superior sensing and response actions, offering tremendous potential for innovative cellular …

B lymphocytes have become a very popular therapeutic target in a number of autoimmune
indications due to their newly appreciated roles, and approachability, in these diseases …

The secreted products of cells drive many functions in vivo; however, methods to link this
functional information to surface markers and transcriptomes have been lacking. By …

Synthetic biology holds great promise to improve the safety and efficacy of future gene and
engineered cell therapies by providing new means of endogenous or exogenous control of …

Synthetic biology and deep learning synergistically revolutionize our ability for decoding and
recoding DNA regulatory grammar. The B-cell-specific transcriptional regulation is intricate …

Posttransplant lymphoproliferative disease (PTLD) is a major therapeutic challenge that has
been difficult to study using human cells because of a lack of suitable models for …

Barriers to effective gene therapy for many diseases include the number of modified target
cells required to achieve therapeutic outcomes and host immune responses to expressed …

B cells are the antibody-producing arm of the adaptive immune system and play a critical
role in controlling pathogens. Several groups have now demonstrated the feasibility of using …

Bispecific antibodies are an important tool for the management and treatment of acute
leukemias. As a next step toward clinical translation of engineered plasma cells, we …

Allogeneic cell therapies, such as those involving macrophages or Natural Killer (NK) cells,
are of increasing interest for cancer immunotherapy. However, the current techniques for …