Immunotherapy has become a fourth pillar in the treatment of brain tumors and, when
combined with radiation therapy, may improve patient outcomes and reduce the …

Recurrent high grade glioma patients face a poor prognosis for which no curative treatment
option currently exists. In contrast to prescribing high dose hypofractionated stereotactic …

Simple Summary Using medical imaging data and computational models, we develop a
modeling framework to provide personalized treatment response forecasts to fractionated …

Background There are limited effective drugs that can reach the brain to target brain tumors,
in particular glioblastoma, which is one of the most difficult cancers to be cured from …

Tumor vasculatures and hypoxia are critical tumor micro-environmental factors associated
with tumor response to the therapy and heterogeneous in both time-and location-dependent …

Glioblastoma multiforme (GBM) is an aggressive primary brain cancer with a grim prognosis.
Its morphology is heterogeneous, but prototypically consists of an inner, largely necrotic core …

Abstract Background and Objectives We extend the original mathematical model, ie,
Swanson's reaction-diffusion equation to the surfaces with no boundary, and we find a new …

Background: Glioblastomas (GBMs) are aggressive malignant brain tumors. Although
chemotherapy with temozolomide (TMZ) can extend patient survival, most patients …

Mathematical modelling of tumor growth is one of the most useful and inexpensive
approaches to determine and predict the stage, size and progression of tumors in realistic …

Recurrent high grade glioma patients face a poor prognosis for which no curative treatment
option currently exists. In contrast to prescribing high dose hypofractionated stereotactic …