Metals to combat antimicrobial resistance
Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …
Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design
G Bahr, LJ Gonzalez, AJ Vila - Chemical reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …
spread of genes coding for resistance determinants among bacteria challenges the use of …
Metalloenzyme mimicry and modulation strategies to conquer antimicrobial resistance: Metal-ligand coordination perspectives
The incessant resistivity of pathogenic microbes to antibiotics continuously constitutes a
major threat to human wellness, thus, searching for effective therapeutic approaches …
major threat to human wellness, thus, searching for effective therapeutic approaches …
Pyrrole-pyridine chelating motif on the β-carboline skeleton: Selective Zn2+ sensing via inhibition of ESIPT
This paper examines the suitability of azaindole appended pyridine core for selective
sensing of Zn 2+. The designed probe (TryPy) was prepared from biologically important …
sensing of Zn 2+. The designed probe (TryPy) was prepared from biologically important …
Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases
A Proschak, G Martinelli, D Frank, MJ Rotter… - European journal of …, 2022 - Elsevier
Carbapenemases such as metallo-β-lactamases (MBLs) are spreading among Gram-
negative bacterial pathogens. Infections due to these multidrug-resistant bacteria constitute …
negative bacterial pathogens. Infections due to these multidrug-resistant bacteria constitute …
Betaxolol as a Potent Inhibitor of NDM-1-Positive E. coli That Synergistically Enhances the Anti-Inflammatory Effect in Combination with Meropenem
J Sun, S Ren, Y Yang, X Li, X Zhang - International Journal of Molecular …, 2023 - mdpi.com
With significant human and economic losses, increasing bacterial resistance is a serious
global threat to human life. Due to their high efficacy, broad spectrum, and cost …
global threat to human life. Due to their high efficacy, broad spectrum, and cost …
Phenotypic and in silico studies for a series of synthetic thiosemicarbazones as New Delhi metallo-beta-lactamase carbapenemase inhibitors
JS Moreira, DS Galvão, CFC Xavier… - Journal of …, 2022 - Taylor & Francis
The past two decades have been marked by a global spread of bacterial resistance to β-
lactam drugs and carbapenems derivatives are the ultimate treatment against multidrug …
lactam drugs and carbapenems derivatives are the ultimate treatment against multidrug …
同时产碳青霉烯酶NDM-1 和NDM-5 的猪源大肠埃希氏菌的鉴定及耐药性研究
李海利， 郎利敏， 张青娴， 游一， 朱文豪， 王治方… - 生物技术 …, 2022 - biotech.aiijournal.com
为了解携带碳青霉烯酶NDM-1 及其亚型在猪场的流行情况, 对来自猪场产房仔猪腹泻病例分离
鉴定的87 株大肠杆菌进行了碳青霉烯酶NDM-1 和NDM-5 的耐药基因扩增及测序. 从87 …
鉴定的87 株大肠杆菌进行了碳青霉烯酶NDM-1 和NDM-5 的耐药基因扩增及测序. 从87 …
Small-molecule inhibitors of bacterial-producing metallo-β-lactamases: insights into their resistance mechanisms and biochemical analyses of their activities
Antibiotic resistance (AR) remains one of the major threats to the global healthcare system,
which is associated with alarming morbidity and mortality rates. The defence mechanisms of …
which is associated with alarming morbidity and mortality rates. The defence mechanisms of …
The Role of Divalent Cations in Antibiotic Sensitivity: A Molecular Aspect
AAAF Amara - Biomolecules from Natural Sources: Advances …, 2022 - Wiley Online Library
This chapter covers five main elements which are: the ions including the divalent cations, the
antibiotics particularly those affected by the presence of the divalent cations and the …
antibiotics particularly those affected by the presence of the divalent cations and the …