HGF and MET: from brain development to neurological disorders

C Desole, S Gallo, A Vitacolonna… - Frontiers in Cell and …, 2021 - frontiersin.org
Hepatocyte growth factor (HGF) and its tyrosine kinase receptor, encoded by the MET
cellular proto-oncogene, are expressed in the nervous system from pre-natal development …

Perturbation of maternal gut microbiota in mice during a critical perinatal window influences early neurobehavioral outcomes in offspring

C Morel, IM Sanchez, Y Cherifi, N Chartrel… - Neuropharmacology, 2023 - Elsevier
The gut microbiota is increasingly recognized as a key environmental factor that shapes host
development and physiology, including neural circuits formation and function. Concurrently …

Bacterial peptidoglycans from microbiota in neurodevelopment and behavior

A Gonzalez-Santana, RD Heijtz - Trends in molecular medicine, 2020 - cell.com
It is increasingly recognized that the gut microbiota profoundly influences many aspects of
host development and physiology, including the modulation of brain development and …

Polychlorinated biphenyls (PCBs): risk factors for autism spectrum disorder?

HK Panesar, CL Kennedy, KP Keil Stietz, PJ Lein - Toxics, 2020 - mdpi.com
Autism spectrum disorder (ASD) includes a group of multifactorial neurodevelopmental
disorders defined clinically by core deficits in social reciprocity and communication …

A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders

L Lombardi, S Le Clerc, CL Wu, J Bouassida… - Translational …, 2023 - nature.com
Autism spectrum disorders (ASD) are neurodevelopmental conditions that are for subsets of
individuals, underpinned by dysregulated immune processes, including inflammation …

[HTML][HTML] Precision in the development of neocortical architecture: from progenitors to cortical networks

RJ Kast, P Levitt - Progress in neurobiology, 2019 - Elsevier
Of all brain regions, the 6-layered neocortex has undergone the most dramatic changes in
size and complexity during mammalian brain evolution. These changes, occurring in the …

Gene× environment interactions in autism spectrum disorders

K Keil-Stietz, PJ Lein - Current topics in developmental biology, 2023 - Elsevier
There is credible evidence that environmental factors influence individual risk and/or
severity of autism spectrum disorders (hereafter referred to as autism). While it is likely that …

Autism-specific maternal autoantibodies produce behavioral abnormalities in an endogenous antigen-driven mouse model of autism

KL Jones, MC Pride, E Edmiston, M Yang… - Molecular …, 2020 - nature.com
Immune dysregulation has been noted consistently in individuals with autism spectrum
disorder (ASD) and their families, including the presence of autoantibodies reactive to fetal …

Maternal autoantibody related autism: mechanisms and pathways

KL Jones, J Van de Water - Molecular psychiatry, 2019 - nature.com
It has been estimated that autism spectrum disorder (ASD) now affects 1 in 59 children in the
United States. Although the cause (s) of ASD remain largely unknown, it is becoming …

Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients

B Castelijns, ML Baak, IS Timpanaro… - Nature …, 2020 - nature.com
Speciation is associated with substantial rewiring of the regulatory circuitry underlying the
expression of genes. Determining which changes are relevant and underlie the emergence …