Mammalian kidneys are specialized to maintain fluid and electrolyte homeostasis. The
epithelial transport processes along the renal tubule that match output to input have long …

Kidney fibrosis is the final common pathway of virtually all chronic kidney diseases (CKDs)
and is therefore considered to be a promising therapeutic target for these conditions …

Kidney failure is frequently observed during and after COVID-19, but it remains elusive
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …

Background Current management of AKI, a potentially fatal disorder that can also initiate or
exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular …

Background Single-cell sequencing technologies have advanced our understanding of
kidney biology and disease, but the loss of spatial information in these datasets hinders our …

Background AKI triggers a proliferative response as part of an intrinsic cellular repair
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …

Mammalian organs exhibit distinct physiology, disease susceptibility, and injury responses
between the sexes. In the mouse kidney, sexually dimorphic gene activity maps …

Emerging spatially resolved transcriptomics technologies allow for the measurement of gene
expression in situ at cellular resolution. We apply direct RNA hybridization-based in situ …

Altered cellular metabolism in kidney proximal tubule (PT) cells plays a critical role in acute
kidney injury (AKI). The transcription factor Krüppel-like factor 6 (KLF6) is rapidly and …

Abstract palmitoylation, a reversible post-translational modification, is initiated by the DHHC
family of palmitoyltransferases and reversed by several acyl protein thioesterases. However …