Η νόσος του Parkinson (PD) είναι μια προοδευτική κινητική νευροεκφυλιστική διαταραχή η
οποία προσβάλλει περίπου το 1% των ενηλίκων ηλικίας άνω των 60 ετών. Οφείλεται στην …

Aos meus pais e minha irmã Aline, por toda confiança, apoio e compreensão a mim dados
para a realização deste mestrado, devo-lhes muito! À minha orientadora, professora …

The innate ability to delivery genetic material to cells makes viruses excellent vectors for
gene delivery [1]. Evasion of the immune system and their ability to control gene expression …

L-dopa is one of the best treatments for the motor symptoms of Parkinson's disease.
However, its use is limited by the fact that it provides only symptomatic relief and chronic …

Le développement d'outils de phénotypage comportemental sophistiqués est indispensable
pour comprendre le fonctionnement cognitif. A partir d'une analyse élaborée de tests …

El sistema renina-angiotensina (SRA) ha sido considerado tradicionalmente como un
sistema circulante, aunque actualmente se sabe que existen SRA locales o tisulares. A nivel …

The field of gene therapy in general has made great progress during the past decade and is
now delivering real treatment to patients with a number of difficult and previously intractable …

The clinical diagnosis of Parkinson disease (PD) is based on the identification of some
combination of the cardinal motor signs of bradykinesia, rigidity, tremor, and postural …

The use of gene therapy has been intensively studied as a potential method to treat
Parkinson's disease (PD) and other degenerative brain diseases. However, the effects of …