Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing

HM Sadeghi, I Adeli, D Calina, AO Docea… - International journal of …, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is an endocrine-gynecology disorder affecting many
women of childbearing age. Although a part of the involved mechanism in PCOS occurrence …

[HTML][HTML] Polycystic ovary syndrome in insulin-resistant adolescents with obesity: the role of nutrition therapy and food supplements as a strategy to protect fertility

V Calcaterra, E Verduci, H Cena, VC Magenes… - Nutrients, 2021 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in young
reproductive-aged women. PCOS is often associated with obesity and impairs reproductive …

[HTML][HTML] Reactive oxygen species and ovarian diseases: Antioxidant strategies

J Liang, Y Gao, Z Feng, B Zhang, Z Na, D Li - Redox Biology, 2023 - Elsevier
Reactive oxygen species (ROS) are mainly produced in mitochondria and are involved in
various physiological activities of the ovary through signaling and are critical for regulating …

The interplay between androgens and the immune response in polycystic ovary syndrome

S Shabbir, E Khurram, VS Moorthi, YTH Eissa… - Journal of Translational …, 2023 - Springer
Polycystic ovary syndrome (PCOS) is a metabolic-reproductive-endocrine disorder that,
while having a genetic component, is known to have a complex multifactorial etiology. As …

Oxidative stress and reproductive function: oxidative stress in polycystic ovary syndrome

E Rudnicka, AM Duszewska, M Kucharski… - …, 2022 - rep.bioscientifica.com
In brief A genetic, epigenetic, and environmental association exists between oxidative stress
(OS) and polycystic ovary syndrome (PCOS), expressed in a multifaceted clinical profile …

Modulation of the inflammatory response in polycystic ovary syndrome (PCOS)—searching for epigenetic factors

D Szukiewicz, S Trojanowski, A Kociszewska… - International journal of …, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of
reproductive age. Despite its incidence, the syndrome is poorly understood and remains …

Aging conundrum: A perspective for ovarian aging

J Wu, Y Liu, Y Song, L Wang, J Ai, K Li - Frontiers in Endocrinology, 2022 - frontiersin.org
Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

Oxidative stress and mitochondrial dysfunction of granulosa cells in polycystic ovarian syndrome

Y Gao, Y Zou, G Wu, L Zheng - Frontiers in Medicine, 2023 - frontiersin.org
Polycystic ovarian syndrome (PCOS) is one of the leading causes of anovulatory infertility in
women, affecting 5%–15% of women of reproductive age worldwide. The clinical …

Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN

R Ji, F Jia, X Chen, Z Wang, W Jin, J Yang - Archives of Biochemistry and …, 2022 - Elsevier
In the past few years, emerging evidence established persistent oxidative stress to be a key
player in the pathogenesis of polycystic ovary syndrome (PCOS). Particularly, it damages …

Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole-induced polycystic ovarian syndrome: targeting PI3K/Akt …

HM Rabah, DA Mohamed, RA Mariah… - Redox …, 2023 - Taylor & Francis
Purpose Polycystic ovary syndrome (PCOS) has a series of reproductive and metabolic
consequences. Although the link between PCOS, IR, and obesity, their impact on the …