Exploring the frontiers of neuroimaging: a review of recent advances in understanding brain functioning and disorders

C Yen, CL Lin, MC Chiang - Life, 2023 - mdpi.com
Neuroimaging has revolutionized our understanding of brain function and has become an
essential tool for researchers studying neurological disorders. Functional magnetic …

Pathobiology of the klotho antiaging protein and therapeutic considerations

GJ Prud'homme, M Kurt, Q Wang - Frontiers in Aging, 2022 - frontiersin.org
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

An insight into cellular and molecular mechanisms underlying the pathogenesis of neurodegeneration in Alzheimer's disease

Y Ratan, A Rajput, S Maleysm, A Pareek, V Jain… - Biomedicines, 2023 - mdpi.com
Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …

Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer's disease

RT Vontell, JP de Rivero Vaccari, X Sun… - Brain …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease that destroys memory
and cognitive function. Inflammasome activation has been suggested to play a critical role in …

The amyloid cascade hypothesis 2.0 for Alzheimer's disease and aging-associated cognitive decline: from molecular basis to effective therapy

V Volloch, S Rits-Volloch - International Journal of Molecular Sciences, 2023 - mdpi.com
With the long-standing amyloid cascade hypothesis (ACH) largely discredited, there is an
acute need for a new all-encompassing interpretation of Alzheimer's disease (AD). Whereas …

Neurodegenerative diseases: Can caffeine be a powerful ally to weaken neuroinflammation?

M Ruggiero, R Calvello, C Porro, G Messina… - International Journal of …, 2022 - mdpi.com
In recent years, there has been considerable research showing that coffee consumption
seems to be beneficial to human health, as it contains a mixture of different bioactive …

LRRK2 Kinase Inhibition Attenuates Neuroinflammation and Cytotoxicity in Animal Models of Alzheimer's and Parkinson's Disease-Related Neuroinflammation

V Mutti, G Carini, A Filippini, S Castrezzati, L Giugno… - Cells, 2023 - mdpi.com
Chronic neuroinflammation plays a crucial role in the progression of several
neurodegenerative diseases (NDDs), including Parkinson's disease (PD) and Alzheimer's …

Orthogonal latent space learning with feature weighting and graph learning for multimodal Alzheimer's disease diagnosis

Z Chen, Y Liu, Y Zhang, Q Li… - Medical Image …, 2023 - Elsevier
Recent studies have shown that multimodal neuroimaging data provide complementary
information of the brain and latent space-based methods have achieved promising results in …

Multimodal fusion of multiple rest fMRI networks and MRI gray matter via parallel multilink joint ICA reveals highly significant function/structure coupling in Alzheimer's …

KMI Khalilullah, O Agcaoglu, J Sui, T Adali… - Human Brain …, 2023 - Wiley Online Library
In this article, we focus on estimating the joint relationship between structural magnetic
resonance imaging (sMRI) gray matter (GM), and multiple functional MRI (fMRI) intrinsic …

Enhancing multimodal patterns in neuroimaging by siamese neural networks with self-attention mechanism

JE Arco, A Ortiz, NJ Gallego-Molina… - … Journal of Neural …, 2023 - World Scientific
The combination of different sources of information is currently one of the most relevant
aspects in the diagnostic process of several diseases. In the field of neurological disorders …