Drug treatments for covid-19: living systematic review and network meta-analysis
Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19).
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …
Kill or corrupt: Mechanisms of action and drug-resistance of nucleotide analogues against SARS-CoV-2
Nucleoside/tide analogues (NAs) have long been used in the fight against viral diseases,
and now present a promising option for the treatment of COVID-19. Once activated to the 5 …
and now present a promising option for the treatment of COVID-19. Once activated to the 5 …
[HTML][HTML] Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates
Dear Editor, Omicron (B. 1.1. 529), is a heavily mutated and highly contagious SARS-CoV-2
variant, which is currently causing large outbreaks in many countries. Protection provided by …
variant, which is currently causing large outbreaks in many countries. Protection provided by …
[HTML][HTML] The efficacy and adverse effects of favipiravir on patients with COVID-19: A systematic review and meta-analysis of published clinical trials and observational …
Objectives This study aimed to evaluate the efficacy and adverse events of favipiravir in
patients with COVID-19. Methods Our protocol was registered on PROSPERO …
patients with COVID-19. Methods Our protocol was registered on PROSPERO …
[HTML][HTML] Drug repositioning in the COVID-19 pandemic: fundamentals, synthetic routes, and overview of clinical studies
ES Vaz, SV Vassiliades, J Giarolla, MC Polli… - European Journal of …, 2023 - Springer
Introduction Drug repositioning is a strategy to identify a new therapeutic indication for
molecules that have been approved for other conditions, aiming to speed up the traditional …
molecules that have been approved for other conditions, aiming to speed up the traditional …
[HTML][HTML] Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): A randomised, double-blind, 2× 2 factorial placebo-controlled trial of early antiviral therapy in …
Background Early antiviral treatment is effective for Coronavirus Disease 2019 (COVID-19)
but currently available agents are expensive. Favipiravir is routinely used in many countries …
but currently available agents are expensive. Favipiravir is routinely used in many countries …
[HTML][HTML] Increased flexibility of the SARS-CoV-2 RNA-binding site causes resistance to remdesivir
Mutations continue to accumulate within the SARS-CoV-2 genome, and the ongoing
epidemic has shown no signs of ending. It is critical to predict problematic mutations that …
epidemic has shown no signs of ending. It is critical to predict problematic mutations that …
[HTML][HTML] Safety and efficacy of four drug regimens versus standard-of-care for the treatment of symptomatic outpatients with COVID-19: A randomised, open-label, multi …
N Chandiwana, C Kruger, H Johnstone… - …, 2022 - thelancet.com
Background This exploratory study investigated four repurposed anti-infective drug
regimens in outpatients with COVID-19. Methods This phase 2, single centre, randomised …
regimens in outpatients with COVID-19. Methods This phase 2, single centre, randomised …
Nucleoside analogs for management of respiratory virus infections: mechanism of action and clinical efficacy
A Stevaert, E Groaz, L Naesens - Current Opinion in Virology, 2022 - Elsevier
Highlights•We need antiviral drugs for COVID-19 but also other respiratory virus
infections.•Several nucleoside analogs are approved or in advanced clinical trials.•They …
infections.•Several nucleoside analogs are approved or in advanced clinical trials.•They …
[HTML][HTML] Antiviral drug treatment for nonsevere COVID-19: a systematic review and network meta-analysis
T Pitre, R Van Alstine, G Chick, G Leung, D Mikhail… - Cmaj, 2022 - Can Med Assoc
Background: Randomized trial evidence suggests that some antiviral drugs are effective in
patients with COVID-19. However, the comparative effectiveness of antiviral drugs in …
patients with COVID-19. However, the comparative effectiveness of antiviral drugs in …