Th17 cells that secrete the cytokines IL-17A and IL-17F and express lineage-specific
transcription factor RORC (RORγt in mice) represent a distinct lineage of CD4+ T cells …

Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their
involvement in acquired and innate immunity. Increasing evidence now implicates mast cells …

Multiple sclerosis (MS) is a multifocal demyelinating disease of the central nervous system
(CNS) leading to the progressive destruction of the myelin sheath surrounding axons. It can …

Type 17 helper T cells (Th17)—a third class of T cells—and their major cytokine, interleukin-
17, are essential for the defense against certain fungi, extracellular bacteria, and …

Neurodegenerative diseases are characterized by the loss of neurons and/or myelin sheath,
which deteriorate over time and cause dysfunction. Interleukin 17A is the signature cytokine …

Platelets are inflammatory anuclear cells with a well-established role in the development
and manifestation of atherosclerosis. Activated platelets secrete a plethora of chemokines …

IL-17-producing T lymphocytes have been recently shown to comprise a distinct lineage of
proinflammatory T helper cells, termed Th17 cells, that are major contributors to autoimmune …

Abnormal production of inflammatory mediators is believed to play an important role in the
pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a …

Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the
traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of …