Chemical and biophysical signatures of the protein corona in nanomedicine

J Ren, N Andrikopoulos, K Velonia… - Journal of the …, 2022 - ACS Publications
An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous
collection of biomolecular species by nanoparticles in living systems. The protein corona is …

Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

M Xu, Y Qi, G Liu, Y Song, X Jiang, B Du - ACS nano, 2023 - ACS Publications
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

In situ analysis of nanoparticle soft corona and dynamic evolution

D Baimanov, J Wang, J Zhang, K Liu, Y Cong… - Nature …, 2022 - nature.com
How soft corona, the protein corona's outer layer, contributes to biological identity of
nanomaterials is largely because capturing protein composition of the soft corona in situ …

2D Piezoelectric BiVO4 Artificial Nanozyme with Adjustable Vanadium Vacancy for Ultrasound Enhanced Piezoelectric/Sonodynamic Therapy

R Zhao, H Zhu, L Feng, Y Zhu, B Liu, C Yu, S Gai… - Small, 2023 - Wiley Online Library
Increasing the yield of reactive oxygen species (ROS) to enhance oxidative stress in cells is
an eternal goal in cancer therapy. In this study, BiVO4 artificial nanozyme is developed with …

Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent

L Dong, YJ Xu, C Sui, Y Zhao, LB Mao… - Nature …, 2022 - nature.com
Amorphous calcium carbonate plays a key role as transient precursor in the early stages of
biogenic calcium carbonate formation in nature. However, due to its instability in aqueous …

Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T1-weighted MRI

J Zhang, Y Ning, H Zhu, NJ Rotile… - Proceedings of the …, 2023 - National Acad Sciences
SNIO–CBP, a single-nanometer iron oxide (SNIO) nanoparticle functionalized with a type I
collagen-binding peptide (CBP), was developed as a T 1-weighted MRI contrast agent with …

Advanced strategies to evade the mononuclear phagocyte system clearance of nanomaterials

J Lu, X Gao, S Wang, Y He, X Ma, T Zhang, X Liu - Exploration, 2023 - Wiley Online Library
Nanomaterials are promising carriers to improve the bioavailability and therapeutic
efficiency of drugs by providing preferential drug accumulation at their sites of action, but …

Penetration and translocation of functional inorganic nanomaterials into biological barriers

Y Cong, D Baimanov, Y Zhou, C Chen… - Advanced Drug Delivery …, 2022 - Elsevier
With excellent physicochemical properties, inorganic nanomaterials (INMs) have exhibited a
series of attractive applications in biomedical fields. Biological barriers prevent successful …

[HTML][HTML] Harnessing reactive oxygen/nitrogen species and inflammation: Nanodrugs for liver injury

M Liu, Q Huang, Y Zhu, L Chen, Y Li, Z Gong, K Ai - Materials Today Bio, 2022 - Elsevier
Overall, 12% of the global population (800 million) suffers from liver disease, which causes 2
million deaths every year. Liver injury involving characteristic reactive oxygen/nitrogen …

Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

KR Gajbhiye, R Salve, M Narwade, A Sheikh… - Molecular Cancer, 2023 - Springer
Lipid-based polymeric nanoparticles are the highly popular carrier systems for cancer drug
therapy. But presently, detailed investigations have revealed their flaws as drug delivery …