Brain accumulation and toxicity profiles of silica nanoparticles: the influence of size and exposure route

W Wei, Z Yan, X Liu, Z Qin, X Tao, X Zhu… - Environmental …, 2022 - ACS Publications
Nanoparticles (NPs) can make their way to the brain and cause in situ damage, which is a
concern for nanomaterial application and airborne particulate matter exposure. Our recent …

High‐Precision Synthesis of RNA‐Loaded Lipid Nanoparticles for Biomedical Applications

H Seo, L Jeon, J Kwon, H Lee - Advanced Healthcare …, 2023 - Wiley Online Library
The recent development of RNA‐based therapeutics in delivering nucleic acids for gene
editing and regulating protein translation has led to the effective treatment of various …

Iterative nanoparticle bioengineering enabled by x-ray fluorescence imaging

GM Saladino, B Brodin, R Kakadiya, MS Toprak… - Science …, 2024 - science.org
Nanoparticles (NPs) are currently developed for drug delivery and molecular imaging.
However, they often get intercepted before reaching their target, leading to low targeting …

Multimodal Tetrahedral DNA Nanoplatform for Surprisingly Rapid and Significant Treatment of Acute Liver Failure

H Wei, K Yi, F Li, D Li, J Yang, R Shi, Y Jin… - Advanced …, 2023 - Wiley Online Library
Acute liver failure (ALF) is a life‐threatening disease associated with the rapid development
of inflammatory storms, level elevation of reactive oxygen species (ROS), and hepatocyte …

Designing smart iron oxide nanoparticles for MR imaging of tumors

Z Li, R Bai, J Yi, H Zhou, J Xian… - Chemical & Biomedical …, 2023 - ACS Publications
Iron oxide nanoparticles (IONPs) possess unique magnetism and good biocompatibility, and
they have been widely applied as contrast agents (CAs) for magnetic resonance imaging …

[HTML][HTML] Remodeling the hepatic fibrotic microenvironment with emerging nanotherapeutics: a comprehensive review

X Zhao, FK Amevor, X Xue, C Wang, Z Cui… - Journal of …, 2023 - Springer
Liver fibrosis could be the last hope for treating liver cancer and remodeling of the hepatic
microenvironment has emerged as a strategy to promote the ablation of liver fibrosis. In …

[HTML][HTML] Nickel nanoparticles induced hepatotoxicity in mice via lipid-metabolism-dysfunction-regulated inflammatory injury

S Zhou, H Li, H Wang, R Wang, W Song, D Li, C Wei… - Molecules, 2023 - mdpi.com
Nickel nanoparticles (NiNPs) have wide applications in industry and biomedicine due to
their unique characteristics. The liver is the major organ responsible for nutrient metabolism …

[HTML][HTML] Role of tunable gold nanostructures in cancer nanotheranostics: implications on synthesis, toxicity, clinical applications and their associated opportunities and …

A Kumar, N Das, RG Rayavarapu - Journal of Nanotheranostics, 2023 - mdpi.com
The existing diagnosis and treatment modalities have major limitations related to their
precision and capability to understand several stages of disease development. A superior …

Peptide‐Based Nanoarchitectonics for the Treatment of Liver Fibrosis

B Li, Y Huang, Q Zou - ChemBioChem, 2023 - Wiley Online Library
Liver fibrosis is a process of excessive accumulation of extracellular matrix caused by liver
injury. Liver fibrosis can progress to cirrhosis or even liver cancer without proper …

[HTML][HTML] PROTACs: Current and Future Potential as a Precision Medicine Strategy to Combat Cancer

KA Rutherford, KJ McManus - Molecular Cancer Therapeutics, 2024 - AACR
Proteolysis targeting chimeras (PROTAC) are an emerging precision medicine strategy,
which targets key proteins for proteolytic degradation to ultimately induce cancer cell killing …