Drug transporters can govern the absorption, distribution, metabolism, and excretion of
substrate drugs and endogenous substances. Investigations to examine their potential …

Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …

Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK …

Physiologically‐based pharmacokinetic (PBPK) modeling has been extensively used to
quantitatively translate in vitro data and evaluate temporal effects from drug–drug …

The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …

To address the most appropriate endogenous biomarker for drug–drug interaction risk
assessment, eight healthy subjects received an organic anion transporting polypeptide 1B …

Purpose To evaluate association of the dose-dependent effect of rifampicin, an OATP1B
inhibitor, on the plasma concentration–time profiles among OATP1B substrates drugs and …

During the last decade high-throughput in vitro absorption, distribution, metabolism and
excretion (HT-ADME) screening has become an essential part of any drug discovery effort of …

Pharmacokinetic drug–drug interactions (DDIs) occur when a drug alters the absorption,
transport, distribution, metabolism or excretion of a co-administered agent. The occurrence …

Abstract Introduction Coproporphyrin (CP) I and III have recently been proposed as
endogenous clinical biomarkers to predict organic anion-transporting polypeptide 1B …