Immunotherapy in hematologic malignancies: achievements, challenges and future prospects

L Tang, Z Huang, H Mei, Y Hu - Signal Transduction and Targeted …, 2023 - nature.com
The immune-cell origin of hematologic malignancies provides a unique avenue for the
understanding of both the mechanisms of immune responsiveness and immune escape …

Immunotherapy in hematologic malignancies: past, present, and future

A Im, SZ Pavletic - Journal of hematology & oncology, 2017 - Springer
The field of immunotherapy in cancer treatments has been accelerating over recent years
and has entered the forefront as a leading area of ongoing research and promising …

Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation

H Guo, YJ Chang, Y Hong, LP Xu, Y Wang… - Cellular & molecular …, 2021 - nature.com
Haploidentical stem cell transplantation (haplo-SCT) achieves superior or at least
comparable clinical outcomes to HLA-matched sibling donor transplantation (MSDT) in …

Haploidentical allograft is superior to matched sibling donor allograft in eradicating pre-transplantation minimal residual disease of AML patients as determined by …

YJ Chang, Y Wang, YR Liu, LP Xu, XH Zhang… - Journal of hematology & …, 2017 - Springer
Background This study compared the effects of pre-transplantation minimal residual disease
(pre-MRD) on outcomes in AML patients who underwent human leukocyte antigen-matched …

Haploidentical donor is preferred over matched sibling donor for pre-transplantation MRD positive ALL: a phase 3 genetically randomized study

YJ Chang, Y Wang, LP Xu, XH Zhang, H Chen… - Journal of hematology & …, 2020 - Springer
Background Previous reports suggest a benefit associated with haploidentical donor
transplantation (HIDT) compared to matched sibling donor transplantation (MSDT) in certain …

[PDF][PDF] Acute graft-versus-host disease: a brief review

E Aladağ, E Kelkitli, H Göker - Turkish Journal of Hematology, 2020 - jag.journalagent.com
Graft‐versus‐host disease (GvHD) is an important complication that can be observed after
allogeneic hematopoietic stem cell transplantation (allo-HSCT). Acute GvHD (aGvHD) is …

Intestinal Microbiota at Engraftment Influence Acute Graft-Versus-Host Disease via the Treg/Th17 Balance in Allo-HSCT Recipients

L Han, H Jin, L Zhou, X Zhang, Z Fan, M Dai… - Frontiers in …, 2018 - frontiersin.org
Animal models have indicated that intestinal microbiota influence acute graft-versus-host
disease (aGVHD) by modulating immune homeostasis. But, in humans, the mechanism by …

Current status and prospects of hematopoietic stem cell transplantation in China

X Wang, R Huang, X Zhang, X Zhang - Chinese Medical Journal, 2022 - journals.lww.com
Hematopoietic stem cell transplantation (HSCT) is a highly effective and unique medical
procedure for the treatment of most hematological malignancies. The first allogeneic …

Minimal residual disease status determined by multiparametric flow cytometry pretransplantation predicts the outcome of patients with ALL receiving unmanipulated …

XS Zhao, YR Liu, LP Xu, Y Wang… - American journal of …, 2019 - Wiley Online Library
This study evaluated the effects of pretransplantation minimal residual disease (pre‐MRD)
on outcomes of patients with acute lymphoblastic leukemia (ALL) who underwent …

Haploidentical transplantation compared with matched sibling and unrelated donor transplantation for adults with standard‐risk acute lymphoblastic leukaemia in first …

LJ Han, Y Wang, ZP Fan, F Huang… - British journal of …, 2017 - Wiley Online Library
We retrospectively investigated outcomes of haploidentical donor (HID) transplant for adults
with standard‐risk acute lymphoblastic leukaemia (ALL) in first complete remission (CR 1) …