Animal models for COVID-19: advances, gaps and perspectives
C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
Advancement of Engineered Bacteria for Orally Delivered Therapeutics
P Guo, S Wang, H Yue, X Zhang, G Ma, X Li, W Wei - Small, 2023 - Wiley Online Library
The use of bacteria and their biotic components as therapeutics has shown great potential in
the treatment of diseases. Orally delivered bacteria improve patient compliance compared …
the treatment of diseases. Orally delivered bacteria improve patient compliance compared …
Oral mRNA vaccines against infectious diseases-A bacterial perspective
V Jawalagatti, P Kirthika, JH Lee - Frontiers in Immunology, 2022 - frontiersin.org
The mRNA vaccines from Pfizer/BioNTech and Moderna were granted emergency approval
in record time in the history of vaccinology and played an instrumental role in limiting the …
in record time in the history of vaccinology and played an instrumental role in limiting the …
Oral delivery of nucleic acid therapies for local and systemic action
Nucleic acid (NA) therapy has gained importance over the past decade due to its high
degree of selectivity and minimal toxic effects over conventional drugs. Currently …
degree of selectivity and minimal toxic effects over conventional drugs. Currently …
Targeting primary and metastatic tumor growth in an aggressive breast cancer by engineered tryptophan auxotrophic Salmonella Typhimurium
V Jawalagatti, P Kirthika, JH Lee - Molecular Therapy-Oncolytics, 2022 - cell.com
The global cancer burden is growing and accounted for 10 million deaths in 2020. The
resurgence of chemo-and radiation resistance have contributed to the treatment failures in …
resurgence of chemo-and radiation resistance have contributed to the treatment failures in …
Live-Attenuated Salmonella-Based Oral Vaccine Candidates Expressing PCV2d Cap and Rep by Novel Expression Plasmids as a Vaccination Strategy for Mucosal …
KKS Lloren, JH Lee - Vaccines, 2023 - mdpi.com
Oral vaccines are highly envisaged for veterinary applications due to their convenience and
ability to induce protective mucosal immunity as the first line of defense. The present …
ability to induce protective mucosal immunity as the first line of defense. The present …
[HTML][HTML] Salmonella-mediated oral delivery of multiple-target vaccine constructs with conserved and variable regions of SARS-CoV-2 protect against the Delta and …
KKS Lloren, V Jawalagatti, C Hewawaduge… - Microbes and …, 2023 - Elsevier
Since the emergence of the pandemic COVID19 caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), the development of vaccines has been the prime …
syndrome coronavirus 2 (SARS-CoV-2), the development of vaccines has been the prime …
Self-Amplifying RNA: A Second Revolution of mRNA Vaccines against COVID-19
N Silva-Pilipich, U Beloki, L Salaberry, C Smerdou - Vaccines, 2024 - mdpi.com
SARS-CoV-2 virus, the causative agent of COVID-19, has produced the largest pandemic in
the 21st century, becoming a very serious health problem worldwide. To prevent COVID-19 …
the 21st century, becoming a very serious health problem worldwide. To prevent COVID-19 …
Development and evaluation of a mouse model susceptible to severe fever with thrombocytopenia syndrome virus by rAAV-based exogenous human DC-SIGN …
JY Park, S Chandran, C Hewawaduge, JH Lee - Microbial Pathogenesis, 2023 - Elsevier
Experimental animal model is indispensable to evaluate the prophylactic and therapeutic
candidates against severe fever with thrombocytopenia syndrome virus (SFTSV). To …
candidates against severe fever with thrombocytopenia syndrome virus (SFTSV). To …