Menopause marks the end of the reproductive phase of life. Based on epidemiological
studies, abnormal age at natural menopause (ANM) is thought to contribute to a number of …

Background: The influence of testosterone on risk for cardiovascular events in men is
uncertain. Previous observational studies of sex hormones and incident cardiovascular …

Background: The risk of aneurysmal subarachnoid hemorrhage (aSAH) is increased in
postmenopausal women compared with men of similar age, suggesting a role for sex …

Background Sex hormone-binding globulin (SHBG), testosterone and oestradiol have been
associated with many diseases in observational studies; however, the causality of …

Background Accumulating evidence suggested that long-term antibiotic use may alter the
gut microbiome, which has, in turn, been linked to type 2 diabetes. We undertook this study …

Background Kisspeptin has been proposed as an effect biomarker to understand the
mechanisms by which some environmental chemicals adversely affect the human …

Introduction Using body mass index (BMI) as a proxy, previous Mendelian randomization
(MR) studies found total causal effects of general obesity on polycystic ovarian syndrome …

Context Sex hormones have been identified as cardiovascular risk factors, whereas the
relationship between sex hormones and the risk of arrhythmias in men has not yet been well …

Aim This study aims to investigate the associations between genetic risk scores (GRS) for
favourable and unfavourable adiposity and a wide range of adiposity‐related outcomes …

Exposure to Perfluoroalkyl acids (PFAS) can impair human reproductive function, eg, by
delaying or advancing puberty, although their mechanisms of action are not fully …