Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
The need for a human pangenome reference sequence
The reference human genome sequence is inarguably the most important and widely used
resource in the fields of human genetics and genomics. It has transformed the conduct of …
resource in the fields of human genetics and genomics. It has transformed the conduct of …
[HTML][HTML] Stroke in Africa: profile, progress, prospects and priorities
Stroke is a leading cause of disability, dementia and death worldwide. Approximately 70% of
deaths from stroke and 87% of stroke-related disability occur in low-income and middle …
deaths from stroke and 87% of stroke-related disability occur in low-income and middle …
African genetic diversity and adaptation inform a precision medicine agenda
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …
humans more than 300,000 years ago, has resulted in high genetic diversity and …
From target discovery to clinical drug development with human genetics
The substantial investments in human genetics and genomics made over the past three
decades were anticipated to result in many innovative therapies. Here we investigate the …
decades were anticipated to result in many innovative therapies. Here we investigate the …
[HTML][HTML] Ancient DNA and deep population structure in sub-Saharan African foragers
Multiple lines of genetic and archaeological evidence suggest that there were major
demographic changes in the terminal Late Pleistocene epoch and early Holocene epoch of …
demographic changes in the terminal Late Pleistocene epoch and early Holocene epoch of …
[图书][B] First farmers: the origins of agricultural societies
P Bellwood - 2023 - books.google.com
A wide-ranging and accessible introduction to the origins and histories of the first agricultural
populations in many different parts of the world This fully revised and updated second …
populations in many different parts of the world This fully revised and updated second …
[HTML][HTML] Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries
Polygenic risk scores (PRS) are valuable to translate the results of genome-wide association
studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals …
studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals …
Promoting the genomic revolution in Africa through the Nigerian 100K Genome Project
To leverage the genetic diversity in Nigeria, we established the Non-Communicable
Diseases Genetic Heritage Study (NCD-GHS) consortium to help produce a comprehensive …
Diseases Genetic Heritage Study (NCD-GHS) consortium to help produce a comprehensive …
[HTML][HTML] From GWAS to gene: transcriptome-wide association studies and other methods to functionally understand GWAS discoveries
B Li, MD Ritchie - Frontiers in genetics, 2021 - frontiersin.org
Since their inception, genome-wide association studies (GWAS) have identified more than a
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …