Strengths and limitations of in silico tools to assess physicochemical properties, bioactivity, and bioavailability of food-derived peptides

F Rivero-Pino, MC Millan-Linares… - Trends in Food Science …, 2023 - Elsevier
Background Bioactive peptides obtained from different food sources have been proved to
exert several bioactivities, such as antioxidant, antihypertensive, antimicrobial, or anti …

Application of artificial intelligence and machine learning for COVID-19 drug discovery and vaccine design

H Lv, L Shi, JW Berkenpas, FY Dao… - Briefings in …, 2021 - academic.oup.com
The global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2, has led to a dramatic loss of human life worldwide …

sAMPpred-GAT: prediction of antimicrobial peptide by graph attention network and predicted peptide structure

K Yan, H Lv, Y Guo, W Peng, B Liu - Bioinformatics, 2023 - academic.oup.com
Abstract Motivation Antimicrobial peptides (AMPs) are essential components of therapeutic
peptides for innate immunity. Researchers have developed several computational methods …

Accurately identifying hemagglutinin using sequence information and machine learning methods

X Zou, L Ren, P Cai, Y Zhang, H Ding, K Deng… - Frontiers in …, 2023 - frontiersin.org
Introduction Hemagglutinin (HA) is responsible for facilitating viral entry and infection by
promoting the fusion between the host membrane and the virus. Given its significance in the …

Deepm5C: a deep-learning-based hybrid framework for identifying human RNA N5-methylcytosine sites using a stacking strategy

MM Hasan, S Tsukiyama, JY Cho, H Kurata, MA Alam… - Molecular Therapy, 2022 - cell.com
As one of the most prevalent post-transcriptional epigenetic modifications, N5-
methylcytosine (m5C) plays an essential role in various cellular processes and disease …

AMYPred-FRL is a novel approach for accurate prediction of amyloid proteins by using feature representation learning

P Charoenkwan, S Ahmed, C Nantasenamat… - Scientific reports, 2022 - nature.com
Amyloid proteins have the ability to form insoluble fibril aggregates that have important
pathogenic effects in many tissues. Such amyloidoses are prominently associated with …

DeepIPs: comprehensive assessment and computational identification of phosphorylation sites of SARS-CoV-2 infection using a deep learning-based approach

H Lv, FY Dao, H Zulfiqar, H Lin - Briefings in Bioinformatics, 2021 - academic.oup.com
The rapid spread of SARS-CoV-2 infection around the globe has caused a massive health
and socioeconomic crisis. Identification of phosphorylation sites is an important step for …

STALLION: a stacking-based ensemble learning framework for prokaryotic lysine acetylation site prediction

S Basith, G Lee, B Manavalan - Briefings in Bioinformatics, 2022 - academic.oup.com
Protein post-translational modification (PTM) is an important regulatory mechanism that
plays a key role in both normal and disease states. Acetylation on lysine residues is one of …

TPpred-ATMV: therapeutic peptide prediction by adaptive multi-view tensor learning model

K Yan, H Lv, Y Guo, Y Chen, H Wu, B Liu - Bioinformatics, 2022 - academic.oup.com
Motivation Therapeutic peptide prediction is important for the discovery of efficient
therapeutic peptides and drug development. Researchers have developed several …

H2Opred: a robust and efficient hybrid deep learning model for predicting 2'-O-methylation sites in human RNA

NT Pham, R Rakkiyapan, J Park, A Malik… - Briefings in …, 2024 - academic.oup.com
O-methylation (2OM) is the most common post-transcriptional modification of RNA. It plays a
crucial role in RNA splicing, RNA stability and innate immunity. Despite advances in high …