Molecular Mechanisms and Potential Antiviral Strategies of Liquid–Liquid Phase Separation during Coronavirus Infection

Y Wang, L Zhou, X Wu, S Yang, X Wang, Q Shen, Y Liu… - Biomolecules, 2024 - mdpi.com
Highly pathogenic coronaviruses have caused significant outbreaks in humans and animals,
posing a serious threat to public health. The rapid global spread of severe acute respiratory …

SHIFTR enables the unbiased identification of proteins bound to specific RNA regions in live cells

J Aydin, A Gabel, S Zielinski, S Ganskih… - Nucleic Acids …, 2024 - academic.oup.com
RNA-protein interactions determine the cellular fate of RNA and are central to regulating
gene expression outcomes in health and disease. To date, no method exists that is able to …

Phosphorylation in the Ser/Arg-rich region of the nucleocapsid of SARS-CoV-2 regulates phase separation by inhibiting self-association of a distant helix

H Stuwe, PN Reardon, Z Yu, S Shah, K Hughes… - Journal of Biological …, 2024 - ASBMB
The nucleocapsid protein (N) of SARS-CoV-2 is essential for virus replication, genome
packaging, evading host immunity, and virus maturation. N is a multidomain protein …

Bioinformatics Insights on Viral Gene Expression Transactivation: From HIV-1 to SARS-CoV-2

R Patarca, WA Haseltine - International Journal of Molecular Sciences, 2024 - mdpi.com
Viruses provide vital insights into gene expression control. Viral transactivators, with other
viral and cellular proteins, regulate expression of self, other viruses, and host genes with …

A KIF1C-CNBP motor-adaptor complex for trafficking mRNAs to cell protrusions

K Moissoglu, T Wang, AN Gasparski, M Stueland… - bioRxiv, 2024 - biorxiv.org
mRNA localization to subcellular compartments is a widely used mechanism that
functionally contributes to numerous processes. mRNA targeting can be achieved upon …

Clinical Symptom Influence on The Time of Nucleic Acid Conversion to Negative in COVID-19 Patients with SARS-CoV-2 Omicron Variant: A Retrospective …

H Feng, X Hong, S Qiu, S Ma, Y Huang - 2024 - advance.sagepub.com
Clinical Symptom Influence on The Time of Nucleic Acid Conversion to Negative in COVID-19
Patients with SARS-CoV-2 Omicron Varia Page 1 P osted on 28 Aug 2024 — The cop yrigh …

Phosphorylation of SARS-CoV-2 N Protein Inhibits Self-Association in Linker Region

S Shah - 2024 - ir.library.oregonstate.edu
The nucleocapsid protein (N) of SARS-CoV-2 is essential for virus replication, genome
packaging, evading host immunity, and virus maturation. N is a multidomain protein …