Calorie restriction (CR) is a dietary regimen that reduces calorie intake without incurring
malnutrition or a reduction in essential nutrients. It has long been recognized as a natural …

Aims/hypothesis Plasma ceramide concentrations correlate with insulin sensitivity,
inflammation and atherosclerotic risk. We hypothesised that plasma ceramide …

Sphingolipids represent one of the major classes of eukaryotic lipids. They play an essential
structural role, especially in cell membranes where they also possess signaling properties …

Metabolic disease, including obesity and type 2 diabetes, constitutes a major emerging
health crisis in Western nations. Although the symptoms and clinical pathology and …

Results: pBMI was significantly associated with 40 metabolites. Nonesterified fatty acids
(NEFA) showed a strong positive association with pBMI, with specificity for mono …

Sphingolipids, a major class of lipids in cell membranes, play diverse roles in biological
processes. As bioactive and structural molecules, they have signaling activities and …

Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and
promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells. This leads …

Farber disease (FD) is a severe inherited disorder of lipid metabolism characterized by
deficient lysosomal acid ceramidase (ACDase) activity, resulting in ceramide accumulation …

Adipose dysfunction resulting from chronic inflammation and impaired adipogenesis has
increasingly been recognized as a major contributor to obesity-mediated insulin resistance …

Abstract Type 2 diabetes (T2D), a heterogeneous disorder derived from metabolic
dysfunctions, leads to a glucose overflow in the circulation due to both defective insulin …