The major risk factors and etiological agents responsible for development of hepatocellular
carcinoma in humans have been identified and characterized. Among these are chronic …

Background/Aims: The natural outcome of ultrasound-detected macronodules in cirrhosis is
still poorly understood. In this study we assessed the incidence and predictors of malignant …

Background: Although liver cancer arises frequently in the course of genetic
hemochromatosis (GH), it has not been previously studied in a large series of patients with …

The bcl-2 protein, which prolongs cell survival by blocking apoptosis, is expressed by
progenitor cells in several self-renewing tissues and by tumoral cells in some extrahepatic …

Liver biopsy plays a central role in treatment algorithms in patients with hepatitis B and
remains the gold standard for evaluating hepatic pathology. The pathology of hepatitis B is …

This report shows that loss of heterozygosity at the mannose 6-phosphate/insulin-like growth
factor II receptor (M6P/IGF2R) locus occurred in 5/8 (63%) dysplastic liver lesions and 11/18 …

The early stages of hepatocarcinogenesis in human chronic liver diseases are characterized
by the emergence of preneoplastic lesions of which some will eventually develop into …

Sublobular nodules of hepatocytes free of iron or exhibiting much less iron than the
surrounding parenchyma, referred to in this study as iron‐free‐foci, are frequently found in …

Background/Aims: In humans, the role of liver cell dysplasia as a preneoplastic lesion is still
debated. A prospective, long-term, multicenter study was performed to establish whether …

Five cases of an adenomatous hyperplastic nodule or a similar lesion resected from a
cirrhotic liver in which early malignant foci were seen as small nodule-in-nodule lesions are …