The aim of this study was to identify high‐risk patients for hepatocellular carcinoma (HCC).
Among 151 patients with histologically proven cirrhosis hospitalized from 1987 to 1990 and …

Hepatocarcinogenesis in the cirrhotic liver has recently become a subject of intense
investigation. The development of hepatocellular nodules demonstrating varying degrees of …

Background/Aims: In humans, the role of liver cell dysplasia as a preneoplastic lesion is still
debated. A prospective, long-term, multicenter study was performed to establish whether …

Background/Aims: In previous studies we found strong evidence for the existence and
activation in human liver of putative progenitor cells resembling oval cells in rat liver. In view …

Telomere shortening and inactivation of cell cycle checkpoints characterize carcinogenesis.
Whether these molecular features coincide at specific stages of human …

Recently, new pathomorphologic information about early-stage small hepatocellular
carcinoma (HCC) and the multi-step process of human hepatocarcinogenesis has been …

Precancerous lesions that may be detected in chronically diseased, usually cirrhotic livers,
include: clusters of hepatocytes with atypia and increased proliferative rate (dysplastic foci) …

Magnetic resonance signal intensity of focal liver lesions is affected by numerous pathologic
factors. Lesion histologic features, such as cellularity, vascularity, stromal component, and …

The incidence of hepatocellular carcinoma (HCC) shows marked variation worldwide but the
magnitude of this tumor is reflected by the occurrence of at least 1 million new cases …

The major pathological findings in 23 patients with hereditary tyrosinemia type I seen at the
Hôpital Sainte-Justine over a 23-year period are reviewed in combination with findings in …