[HTML][HTML] Pathogenesis of allergic diseases and implications for therapeutic interventions

J Wang, Y Zhou, H Zhang, L Hu, J Liu, L Wang… - Signal transduction and …, 2023 - nature.com
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

[HTML][HTML] The M1 and M2 paradigm of macrophage activation: time for reassessment

FO Martinez, S Gordon - F1000prime reports, 2014 - ncbi.nlm.nih.gov
Macrophages are endowed with a variety of receptors for lineage-determining growth
factors, T helper (Th) cell cytokines, and B cell, host, and microbial products. In tissues …

Allergic endotypes and phenotypes of asthma

N Akar-Ghibril, T Casale, A Custovic… - The Journal of Allergy …, 2020 - Elsevier
Allergic asthma is defined as asthma associated with sensitization to aeroallergens, which
leads to asthma symptoms and airway inflammation. Allergic asthma is the most common …

Цитокины в патогенезе и лечении заболеваний человека

АС Симбирцев - 2018 - elibrary.ru
В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

Cytokines, allergy, and asthma

LP Ngoc, DR Gold, AO Tzianabos… - Current opinion in …, 2005 - journals.lww.com
An enhanced Th2 immune response and the elaboration of cytokines such as IL-4, IL-13,
and IL-5 contribute to the induction of allergy and asthma. Interferon-γ, a Th1 cytokine, acts …

Importance of cytokines in murine allergic airway disease and human asthma

FD Finkelman, SP Hogan, GKK Hershey… - The Journal of …, 2010 - journals.aai.org
Asthma is a common, disabling inflammatory respiratory disease that has increased in
frequency and severity in developed nations. We review studies of murine allergic airway …

Genome-wide association study to identify genetic determinants of severe asthma

YI Wan, NRG Shrine, MS Artigas, LV Wain, JD Blakey… - Thorax, 2012 - thorax.bmj.com
Background The genetic basis for developing asthma has been extensively studied.
However, association studies to date have mostly focused on mild to moderate disease and …

Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation

C Bergeron, LP Boulet - Chest, 2006 - Elsevier
In airway diseases such as asthma and COPD, specific structural changes may be
observed, very likely secondary to an underlying inflammatory process. Although it is still …

The allergic cascade: review of the most important molecules in the asthmatic lung

K Bloemen, S Verstraelen, R Van Den Heuvel… - Immunology letters, 2007 - Elsevier
Asthma is the most common chronic inflammatory disorder of the airways among children. It
is a complex clinical disease characterized by airway obstruction, airway inflammation and …

Asthma and COPD: basic mechanisms and clinical management

PJ Barnes, JM Drazen, SI Rennard, NC Thomson - 2009 - books.google.com
The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management
continues to provide a unique and authoritative comparison of asthma and COPD. Written …