NV Volkova, B Meier, V González-Huici… - Nature …, 2020 - nature.com
Cells possess an armamentarium of DNA repair pathways to counter DNA damage and prevent mutation. Here we use C. elegans whole genome sequencing to systematically …
B Honarvari, S Karimifard, N Akhtari, M Mehrarya… - Molecules, 2022 - mdpi.com
As the most common cancer in women, efforts have been made to develop novel nanomedicine-based therapeutics for breast cancer. In the present study, the in silico …
Endocrine disrupting chemicals (EDCs) mimic natural hormones and disrupt endocrine function. Humans and wildlife are exposed to EDCs might alter endocrine functions through …
The development of a novel comprehensive approach for the prediction of h ERG activity is herein presented. Software Phase has been used to derive a 3D-QSAR model, employing …
P Ambure, S Kar, K Roy - Biosystems, 2014 - Elsevier
Alzheimer's disease (AD) is turning out to be one of the lethal diseases in older people. Acetylcholinesterase (AChE) is a crucial target in designing of drugs against AD. The …
Aim: Both endothelin ET A receptor antagonists and angiotensin AT 1 receptor antagonists lower blood pressure in hypertensive patients. A dual AT 1 and ET A receptor antagonist …
K Hengphasatporn, A Garon, P Wolschann… - Scientia …, 2020 - mdpi.com
Dengue infection is caused by a mosquito-borne virus, particularly in children, which may even cause death. No effective prevention or therapeutic agents to cure this disease are …
Abstract p300/CBP-associated factor (PCAF) is one among the histone acetyltransferase (HAT) family enzymes. It is involved in the regulation of transcription by modifying the …
The potential of heat shock protein 90 (Hsp90) as a therapeutic target for numerous diseases has made the identification and optimization of novel Hsp90 inhibitors an …