Water scarcity is increasingly a global cause of concern mainly due to widespread changes
in climate conditions and increased consumptive water use driven by the exponential …

The Aryl hydrocarbon receptor (AhR) is a critical regulator of both innate and adaptive
immune responses, with potent immunomodulatory effects that makes this receptor an …

Tumors accumulate metabolites that deactivate infiltrating immune cells and polarize them
toward anti-inflammatory phenotypes. We provide a comprehensive review of the complex …

Natural killer (NK) cells are key players in the immune system. They use receptors on their
cell surface to identify target cells. However, to escape being killed by the immune system …

Uveitis is characterized as a common cause of blindness worldwide. Aryl hydrocarbon
receptor (AhR), a ligand-activated nuclear receptor, has been implicated to play a role in …

Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to
chemicals including polycyclic aromatic hydrocarbons (PAHs) and polychlorinated dibenzo …

Energy metabolism plays an important role in proliferating cells. Recent reports indicate that
metabolic regulation or metabolic products can control immune cell differentiation, fate and …

In a time where “translational” science has become a mantra in the biomedical field, it is
reassuring when years of research into a biological phenomenon suddenly points towards …

Immunotherapy is emerging as a promising avenue in oncology, gaining increasing
importance and offering substantial advantages when compared to chemotherapy or …

We have postulated that the aryl hydrocarbon receptor (AHR) drives the later, more lethal
stages of some cancers when chronically activated by endogenous ligands. However, other …