Simple Summary The kynurenine pathway (KP) is a biochemical pathway that synthesizes
the vital coenzyme, nicotinamide adenine dinucleotide (NAD+). In cancer, the KP is …

Colchicine binding site inhibitors (CBSIs) have attracted much attention due to their
antitumor efficacies and the advantages of inhibiting angiogenesis and overcoming …

Neuropilin-1 (Nrp1), a transmembrane protein expressed on CD4+ T cells, is mostly studied
in the context of regulatory T cell (Treg) function. More recently, there is increasing evidence …

Activation of the aryl hydrocarbon receptor (AhR) has been shown to be important in
physiological processes other than detoxification, including vascular homeostasis. Although …

The aryl hydrocarbon receptor (AhR) is a crucial cytosolic evolutionary conserved ligand-
activated transcription factor and a pleiotropic signal transducer. The biosensor activity of the …

Aims Chronic lung diseases are a major and increasing global health problem, commonly
caused by cigarette smoke. We aimed to explore the antioxidant effects of lactic acid …

Computational drug-repositioning technology is an effective tool for speeding up drug
development. As biological data resources continue to grow, it becomes more important to …

Simple Summary Chronic lymphocytic leukemia (CLL) is the most common leukemia in
Western countries, mostly affecting the elderly. The survival of leukemic cells depends on …

Lung cancer (LC), one of the most common malignant neoplasms, is the leading cause of
high cancer mortality worldwide. Smoking is a risk factor for almost all histological types of …

PCB 126 is a pervasive, dioxin-like chemical pollutant which can activate the aryl
hydrocarbon receptor (AhR). Despite being banned from the market, PCB 126 can be …