Trypanosoma evansi and Surra: A Review and Perspectives on Origin, History, Distribution, Taxonomy, Morphology, Hosts, and Pathogenic Effects

M Desquesnes, P Holzmuller, DH Lai… - BioMed research …, 2013 - Wiley Online Library
Trypanosoma evansi, the agent of “surra,” is a salivarian trypanosome, originating from
Africa. It is thought to derive from Trypanosoma brucei by deletion of the maxicircle …

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications

MM Alvarez, JC Liu, G Trujillo-de Santiago… - Journal of Controlled …, 2016 - Elsevier
Macrophages are key players in many physiological scenarios including tissue
homeostasis. In response to injury, typically the balance between macrophage sub …

Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity

B Stijlemans, G Caljon, J Van Den Abbeele… - Frontiers in …, 2016 - frontiersin.org
The diseases caused by African trypanosomes (AT) are of both medical and veterinary
importance and have adversely influenced the economic development of sub-Saharan …

Host immune responses and immune evasion strategies in African trypanosomiasis

C Onyilagha, JE Uzonna - Frontiers in immunology, 2019 - frontiersin.org
Parasites, including African trypanosomes, utilize several immune evasion strategies to
ensure their survival and completion of their life cycles within their hosts. The defense factors …

Escaping deleterious immune response in their hosts: lessons from trypanosomatids

A Geiger, G Bossard, D Sereno, J Pissarra… - Frontiers in …, 2016 - frontiersin.org
The Trypanosomatidae family includes the genera Trypanosoma and Leishmania,
protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and …

Prospects for vaccination against pathogenic African trypanosomes

SJ Black, JM Mansfield - Parasite immunology, 2016 - Wiley Online Library
African trypanosomes cause human and animal African trypanosomiases, which are
chronic, debilitating and often fatal diseases of people and livestock in sub‐Saharan Africa …

African trypanosomes undermine humoral responses and vaccine development: link with inflammatory responses?

B Stijlemans, M Radwanska, C De Trez… - Frontiers in …, 2017 - frontiersin.org
African trypanosomosis is a debilitating disease of great medical and socioeconomical
importance. It is caused by strictly extracellular protozoan parasites capable of infecting all …

African Trypanosomiasis: Extracellular Vesicles Shed by Trypanosoma brucei brucei Manipulate Host Mononuclear Cells

T Dias-Guerreiro, J Palma-Marques… - Biomedicines, 2021 - mdpi.com
African trypanosomiasis or sleeping sickness is a zoonotic disease caused by Trypanosoma
brucei, a protozoan parasite transmitted by Glossina spp.(tsetse fly). Parasite introduction …

Tipping the balance between erythroid cell differentiation and induction of anemia in response to the inflammatory pathology associated with chronic trypanosome …

HTT Nguyen, M Radwanska, S Magez - Frontiers in Immunology, 2022 - frontiersin.org
Infection caused by extracellular single-celled trypanosomes triggers a lethal chronic
wasting disease in livestock and game animals. Through screening of 10 Trypanosoma …

A Trypanosoma brucei Kinesin Heavy Chain Promotes Parasite Growth by Triggering Host Arginase Activity

G De Muylder, S Daulouède, L Lecordier… - PLoS …, 2013 - journals.plos.org
Background In order to promote infection, the blood-borne parasite Trypanosoma brucei
releases factors that upregulate arginase expression and activity in myeloid cells …