Immunity to SARS‐CoV‐2 induced by infection or vaccination
Adaptive immune responses play critical roles in viral clearance and protection against re‐
infection, and SARS‐CoV‐2 is no exception. What is exceptional is the rapid …
infection, and SARS‐CoV‐2 is no exception. What is exceptional is the rapid …
The International Mouse Phenotyping Consortium: comprehensive knockout phenotyping underpinning the study of human disease
Abstract The International Mouse Phenotyping Consortium (IMPC; https://www.
mousephenotype. org/) web portal makes available curated, integrated and analysed …
mousephenotype. org/) web portal makes available curated, integrated and analysed …
A dynamic COVID-19 immune signature includes associations with poor prognosis
Improved understanding and management of COVID-19, a potentially life-threatening
disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward …
disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward …
Arming a killer: Mitochondrial regulation of CD8+ T cell cytotoxicity
M Lisci, GM Griffiths - Trends in Cell Biology, 2023 - cell.com
While once regarded as ATP factories, mitochondria have taken the spotlight as important
regulators of cellular homeostasis. The past two decades have witnessed an intensifying …
regulators of cellular homeostasis. The past two decades have witnessed an intensifying …
Mitochondrial translation is required for sustained killing by cytotoxic T cells
M Lisci, PR Barton, LO Randzavola, CY Ma… - Science, 2021 - science.org
INTRODUCTION Cytotoxic T lymphocytes (CTLs) are important cells within the immune
system that are able to recognize and destroy cancer and virally infected cells. Killing is …
system that are able to recognize and destroy cancer and virally infected cells. Killing is …
Normality sensing licenses local T cells for innate-like tissue surveillance
DR McKenzie, R Hart, N Bah, DS Ushakov… - Nature …, 2022 - nature.com
The increasing implication of lymphocytes in general physiology and immune surveillance
outside of infection poses the question of how their antigen receptors might be involved …
outside of infection poses the question of how their antigen receptors might be involved …
Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments
A Jandke, D Melandri, L Monin, DS Ushakov… - Nature …, 2020 - nature.com
Butyrophilin-like (Btnl) genes are emerging as major epithelial determinants of tissue-
associated γδ T cell compartments. Thus, the development of signature, murine TCRγδ+ …
associated γδ T cell compartments. Thus, the development of signature, murine TCRγδ+ …
A consensus Covid-19 immune signature combines immuno-protection with discrete sepsis-like traits associated with poor prognosis
AG Laing, A Lorenc, I Del Molino Del Barrio, A Das… - MedRxiv, 2020 - medrxiv.org
Person-to-person transmission of SARS-CoV-2 virus has triggered a global emergency
because of its potential to cause life-threatening Covid-19 disease. By comparison to …
because of its potential to cause life-threatening Covid-19 disease. By comparison to …
[HTML][HTML] Immune privilege: the microbiome and uveitis
C Mölzer, J Heissigerova, HM Wilson… - Frontiers in …, 2021 - frontiersin.org
Immune privilege (IP), a term introduced to explain the unpredicted acceptance of allogeneic
grafts by the eye and the brain, is considered a unique property of these tissues. However …
grafts by the eye and the brain, is considered a unique property of these tissues. However …
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF
A Hausmann, B Felmy, L Kunz, S Kroon… - Journal of Experimental …, 2021 - rupress.org
Intestinal epithelial cell (IEC) NF-κB signaling regulates the balance between mucosal
homeostasis and inflammation. It is not fully understood which signals tune this balance and …
homeostasis and inflammation. It is not fully understood which signals tune this balance and …