A review on Alzheimer's disease pathophysiology and its management: an update

A Kumar, A Singh - Pharmacological reports, 2015 - Elsevier
Alzheimer's disease acknowledged as progressive multifarious neurodegenerative disorder,
is the leading cause of dementia in late adult life. Pathologically it is characterized by …

Therapeutics of Alzheimer's disease: Past, present and future

R Anand, KD Gill, AA Mahdi - Neuropharmacology, 2014 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …

The impact of microglial activation on blood-brain barrier in brain diseases

ACC da Fonseca, D Matias, C Garcia… - Frontiers in cellular …, 2014 - frontiersin.org
The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs)
together with neurons and glial cells, including microglia, forms the neurovascular unit …

The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization

IW Hamley - Chemical reviews, 2012 - ACS Publications
This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

COVID-19 and Alzheimer's disease

M Ciaccio, B Lo Sasso, C Scazzone, CM Gambino… - Brain sciences, 2021 - mdpi.com
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a neurotropic
virus with a high neuroinvasive potential. Indeed, more than one-third of patients develop …

Inflammatory cascade in Alzheimer's disease pathogenesis: A review of experimental findings

J de Oliveira, E Kucharska, ML Garcez, MS Rodrigues… - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Most AD patients
develop the disease in late life, named late onset AD (LOAD). Currently, the most …

[HTML][HTML] Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

RE Tanzi, L Bertram - Cell, 2005 - cell.com
From Alois Alzheimer's description of Auguste D.'s brain in 1907 to George Glenner's
biochemical dissection of β-amyloid in 1984, the" amyloid hypothesis" of Alzheimer's …

Vascular dysfunction in the pathogenesis of Alzheimer's disease—A review of endothelium-mediated mechanisms and ensuing vicious circles

LY Di Marco, A Venneri, E Farkas, PC Evans… - Neurobiology of …, 2015 - Elsevier
Late-onset dementia is a major health concern in the ageing population. Alzheimer's
disease (AD) accounts for the largest proportion (65–70%) of dementia cases in the older …

Clearance of amyloid-β peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease

R Deane, RD Bell, A Sagare… - CNS & Neurological …, 2009 - ingentaconnect.com
The main receptors for amyloid-beta peptide (Aβ) transport across the blood-brain barrier
(BBB) from brain to blood and blood to brain are low-density lipoprotein receptor related …

Neurovascular mechanisms of Alzheimer's neurodegeneration

BV Zlokovic - Trends in neurosciences, 2005 - cell.com
In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings
indicate that neurovascular dysfunction contributes to cognitive decline and …