Preclinical Investigations on Anti-fibrotic Potential of Long-Term Oral Therapy of Sodium Astragalosidate in Animal Models of Cardiac and Renal Fibrosis

XY Chen, TT Wang, Q Shen, H Ma, ZH Li… - ACS Pharmacology & …, 2024 - ACS Publications
In traditional Chinese medicine, Radix Astragali has played a vital role in treating
progressive fibrotic diseases. One of its main active components, astragaloside IV, is a …

Nanoyttria attenuates isoproterenol-induced cardiac injury

C Godugu, P Kumari, A Khurana - Nanomedicine, 2018 - Taylor & Francis
Aim: The present study was designed to probe the cardioprotective effects of nanoyttria (NY).
Materials & methods: NY was characterized using various techniques. Isoproterenol (ISO) …

Cerulein-induced chronic pancreatitis in Swiss albino mice: An improved short-term model for pharmacological screening

S Bansod, A Khurana, C Godugu - Journal of pharmacological and …, 2019 - Elsevier
There is a need for short-term, reliable and reproducible animal model of chronic
pancreatitis (CP) in small animals like mice. This study was aimed to establish the 9 …

Leveraging the pathophysiological alterations of obstructive nephropathy to treat renal fibrosis by cerium oxide nanoparticles

MA Saifi, CS Peddakkulappagari… - ACS biomaterials …, 2020 - ACS Publications
Chronic kidney disease (CKD) has wide prevalence globally that affects a considerable
population and has renal fibrosis (RF) as a hallmark feature. RF is characterized by …

Dramatic improvement in pharmacokinetic and pharmacodynamic effects of sustain release curcumin microparticles demonstrated in experimental type 1 diabetes …

P Anchi, A Khurana, D Swain, G Samanthula… - European journal of …, 2019 - Elsevier
Curcumin (cur) is a well known plant flavonoid with pleiotropic pharmacological activities.
However, due to its poor bioavailability those therapeutic benefits are still out of reach for …

[HTML][HTML] Protective effects of nanoceria against mitochondrial dysfunction and angiotensin II-induced hypertrophy in H9c2 cardiomyoblasts

R Gul, MA Dar, S Nawaz, AA Alfadda - Antioxidants, 2023 - mdpi.com
Mitochondrial dysfunction triggered by increased reactive oxygen species (ROS) generation
is involved in the pathogenesis and development of cardiac hypertrophy. Nanoceria (cerium …

Effect of Cerium Oxide Nanoparticles on Adriamycin-Induced Nephropathy: Possible Role for Nrf2/HO-1 and TGF-β/Sirt-1 Pathways

FH Elsaid, AA Khalil, EA Eid, M Taha, M El-Nablaway… - BioNanoScience, 2024 - Springer
The current study assessed the impact of cerium oxide nanoparticles (nanocerium, NC) on
adriamycin (ADR)-induced nephropathy in addition to the physiological role of oxidative …

Melatonin Attenuates Extracellular Matrix Accumulation and Cardiac Injury Manifested by Copper

SA Ali, S ‬‬‬‬‬‬‬ Bommaraju, J Patwa, P Khare… - … Trace Element Research, 2023 - Springer
Copper-induced cardiac injury is not widely reported in spite of its ability to cause oxidative
damage and tissue injury. Structural and morphological changes in the cardiac tissue are …

[HTML][HTML] Impact of Cerium Oxide Nanoparticles on Metabolic, Apoptotic, Autophagic and Antioxidant Changes in Doxorubicin-Induced Cardiomyopathy: Possible …

SEEM Elmorshdy, GA Shaker, ZH Eldken… - … of Biochemistry & …, 2023 - ncbi.nlm.nih.gov
Background: In the current study, the effects of cerium oxide nanoparticles (nanocerium; NC)
on doxorubicin (DOX)-induced cardiomyopathy and its possible underlying mechanisms …

[HTML][HTML] Nanoceria and its biomedical relevance

J Kailashiya, D Dash - Annals of the National Academy of …, 2019 - thieme-connect.com
Nanoceria is a nanosized particle preparation of cerium oxide. It shows mixture of cerium in
the 3+ and 4+ states on the nanoparticle surface, giving it interesting redox properties …