Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disease, with a
complex risk structure thought to be influenced by interactions between genetic variants and …

In single-cell RNA sequencing (scRNA-seq), doublets form when two cells are encapsulated
into one reaction volume. The existence of doublets, which appear to be—but are not—real …

Recent advances in single-cell RNA sequencing (scRNA-seq) enable characterization of
transcriptomic profiles with single-cell resolution and circumvent averaging artifacts …

In primates, the amnion emerges through cavitation of the epiblast during implantation,
whereas in other species it does so later at gastrulation by the folding of the ectoderm. How …

Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …

The brain vasculature maintains brain homeostasis by tightly regulating ionic, molecular,
and cellular transport between the blood and the brain parenchyma. These blood–brain …

Methods for single-cell RNA sequencing (scRNA-seq) have greatly advanced in recent
years. While droplet-and well-based methods have increased the capture frequency of cells …

The rapid development of single-cell transcriptomic technologies has helped uncover the
cellular heterogeneity within cell populations. However, bulk RNA-seq continues to be the …

Single-cell profiling techniques create opportunities to delineate cell fate progression in
mammalian development. Recent studies have provided transcriptome data from human pre …

Motivation Single-cell RNA sequencing (scRNA-seq) technologies enable the study of
transcriptional heterogeneity at the resolution of individual cells and have an increasing …