Integrating multiscale modeling with drug effects for cancer treatment
In this paper, we review multiscale modeling for cancer treatment with the incorporation of
drug effects from an applied system's pharmacology perspective. Both the classical …
drug effects from an applied system's pharmacology perspective. Both the classical …
High-throughput binding affinity calculations at extreme scales
Background Resistance to chemotherapy and molecularly targeted therapies is a major
factor in limiting the effectiveness of cancer treatment. In many cases, resistance can be …
factor in limiting the effectiveness of cancer treatment. In many cases, resistance can be …
In Silico Oncology: Quantification of the In Vivo Antitumor Efficacy of Cisplatin-Based Doublet Therapy in Non-Small Cell Lung Cancer (NSCLC) through a Multiscale …
E Kolokotroni, D Dionysiou, C Veith… - PLoS Computational …, 2016 - journals.plos.org
The 5-year survival of non-small cell lung cancer patients can be as low as 1% in advanced
stages. For patients with resectable disease, the successful choice of preoperative …
stages. For patients with resectable disease, the successful choice of preoperative …
Efficient model of tumor dynamics simulated in multi-GPU environment
The application of computer simulation as a tool in predicting cancer dynamics (eg during
anticancer therapy) requires tumor models, which are nontrivial and, simultaneously, not …
anticancer therapy) requires tumor models, which are nontrivial and, simultaneously, not …
[HTML][HTML] The INTEGRATE project: delivering solutions for efficient multi-centric clinical research and trials
H Kondylakis, B Claerhout, M Keyur, L Koumakis… - Journal of biomedical …, 2016 - Elsevier
The objective of the INTEGRATE project (http://www. fp7-integrate. eu/) that has recently
concluded successfully was the development of innovative biomedical applications focused …
concluded successfully was the development of innovative biomedical applications focused …
[HTML][HTML] Multi-scale network targeting: A holistic systems-biology approach to cancer treatment
D Paul, NL Komarova - Progress in biophysics and molecular biology, 2021 - Elsevier
The vulnerabilities of cancer at the cellular and, recently, with the introduction of
immunotherapy, at the tissue level, have been exploited with variable success. Evaluating …
immunotherapy, at the tissue level, have been exploited with variable success. Evaluating …
Integrated segmentation of brain tumor images for radiotherapy and neurosurgery
Segmentation of brain tumor images is an important task in diagnosis and treatment
planning for cancer patients. To achieve this goal with standard clinical acquisition …
planning for cancer patients. To achieve this goal with standard clinical acquisition …
From base pair to bedside: molecular simulation and the translation of genomics to personalized medicine
Despite the promises made that genomic sequencing would transform therapy by
introducing a new era of personalized medicine, relatively few tangible breakthroughs have …
introducing a new era of personalized medicine, relatively few tangible breakthroughs have …
The virtual physiological human
The Virtual Physiological Human is synonymous with a programme in computational
biomedicine that aims to develop a framework of methods and technologies to investigate …
biomedicine that aims to develop a framework of methods and technologies to investigate …
[HTML][HTML] Studying the growth kinetics of untreated clinical tumors by using an advanced discrete simulation model
EA Kolokotroni, DD Dionysiou, NK Uzunoglu… - … and computer modelling, 2011 - Elsevier
Prior to an eventual clinical adaptation and validation of any clinically oriented model, a
thorough study of its dynamic behavior is a sine qua non. Such a study can also elucidate …
thorough study of its dynamic behavior is a sine qua non. Such a study can also elucidate …