Due to the limited effectiveness of current treatments, the survival rate of patients with
metastatic castration-resistant prostate cancer (mCRPC) is significantly reduced …

Pulmonary disorders, including asthma, chronic obstructive pulmonary disease (COPD),
pulmonary fibrosis (PF), pulmonary hypertension (PH), and lung cancer, seriously impair the …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignant disease with a low 5-year
overall survival rate. It is the third-leading cause of cancer-related deaths in the United …

Targeting the protein arginine methyltransferase 1 (PRMT1) has emerged as a promising
therapeutic strategy in cancer treatment. The phase 1 clinical trial for GSK3368715, the first …

In this issue of Blood, Lynch et al 1 reveal that HOXA9 and β-catenin act in concert to
maintain hematopoietic stem cells (HSCs) and preserve their multilineage differentiation …

Cancer is currently the second leading cause of death worldwide as over 500 thousand
patients will succumb to the disease. The development of immune-and targeted therapies …

Arginine methylation is a prevalent post-translational modification in biology present on
0.5% of total arginine proteins in mammalian cells. Protein arginine methylation is a key …

Abstract Protein arginine methyltransferase 1 (PRMT1) is a protein responsible for the
asymmetric dimethylation of arginine. PRMT1 is upregulated in a wide range of cancers and …