Rheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It is
associated with significant burden at the patient and societal level. Extensive efforts have …

The presence of disease-specific autoantibody responses and the efficacy of B cell-targeting
therapies in rheumatoid arthritis (RA) indicate a pivotal role for B cells in disease …

The human immune system displays substantial variation between individuals, leading to
differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing …

Objective The causality and pathogenic mechanism of microbiome composition remain
elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA) …

Macrophages are central to the pathophysiology of rheumatoid arthritis (RA). They constitute
the main source of pro-inflammatory cytokines and chemokines such as TNF and IL-1β, they …

Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease mainly involving
synovial inflammation and articular bone destruction. RA is a heterogeneous disease with …

Background: Evidence for a potential link between air pollution and rheumatoid arthritis (RA)
is inconsistent, and the modified effect of genetic susceptibility on the relationship between …

Abstract Background Long non-coding RNAs (lncRNAs) have drawn increasing attention
because they play a pivotal role in various types of autoimmune diseases, including …