Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
Progress and challenges in targeting the SARS-CoV-2 papain-like protease
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The approval of vaccines
and small-molecule antivirals is vital in combating the pandemic. The viral polymerase …
and small-molecule antivirals is vital in combating the pandemic. The viral polymerase …
Antiviral drug discovery for the treatment of COVID-19 infections
TI Ng, I Correia, J Seagal, DA DeGoey, MR Schrimpf… - Viruses, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), a recently emerged human coronavirus …
respiratory syndrome coronavirus 2 (SARS-CoV-2), a recently emerged human coronavirus …
[HTML][HTML] Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?
C Fu, L Yu, Y Miao, X Liu, Z Yu, M Wei - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Peptide–drug conjugates (PDCs) are the next generation of targeted therapeutics drug after
antibody–drug conjugates (ADCs), with the core benefits of enhanced cellular permeability …
antibody–drug conjugates (ADCs), with the core benefits of enhanced cellular permeability …
Peptide-drug conjugates: a new hope for cancer management
Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …
options for patients. As such, safe and effective therapeutics are required. Short peptides …
Inhibitors of sars-cov-2 plpro
The emergence of SARS-CoV-2 causing the COVID-19 pandemic, has highlighted how a
combination of urgency, collaboration and building on existing research can enable rapid …
combination of urgency, collaboration and building on existing research can enable rapid …
SARS‐CoV‐2 papain‐like protease: structure, function and inhibition
Emerging variants of SARS‐CoV‐2 and potential novel epidemic coronaviruses underline
the importance of investigating various viral proteins as potential drug targets. The papain …
the importance of investigating various viral proteins as potential drug targets. The papain …
Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease
V Srinivasan, H Brognaro, PR Prabhu… - Communications …, 2022 - nature.com
Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …
Traceless Peptide and Protein Modification via Rational Tuning of Pyridiniums
C Wan, Y Zhang, J Wang, Y Xing, D Yang… - Journal of the …, 2024 - ACS Publications
Herein, we report a versatile reaction platform for tracelessly cleavable cysteine-selective
peptide/protein modification. This platform offers highly tunable and predictable conjugation …
peptide/protein modification. This platform offers highly tunable and predictable conjugation …
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal
Unprecedented efforts of the researchers have been witnessed in the recent past towards
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …